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Claremont Colleges

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Physics

2023

Articles 1 - 6 of 6

Full-Text Articles in Physical Sciences and Mathematics

Using Computational Fluid Dynamics And Optical Sensor Technology To Scale Cell Culture Platforms, Mandar Makwana Jan 2023

Using Computational Fluid Dynamics And Optical Sensor Technology To Scale Cell Culture Platforms, Mandar Makwana

KGI Theses and Dissertations

Different cell culture vessels ranging from micro scale to laboratory scale to commercial scale play critical role in upstream process development for biologics manufacturing. Based on the mode of operation, cell culture vessels have different hydrodynamic environments, making it challenging to scale. Integrated approaches using computational tools supported by experimental studies can overcome these challenges. Computational Fluid Dynamics (CFD) is one such tool that can simulate hydrodynamics within the cell culture vessels and can provide insights at macro and micro-scale. Accuracy of a CFD model significantly depends on the fluid model and assumptions. Traditionally, simple two-equation fluid models were developed …

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Analysis Of Biologically Effective Dose For Retroactive Yttrium-90 Trans-Arterial Radioembolization Treatment Optimization, Mj Lindsey Jan 2023

Analysis Of Biologically Effective Dose For Retroactive Yttrium-90 Trans-Arterial Radioembolization Treatment Optimization, Mj Lindsey

CMC Senior Theses

Trans-arterial radioembolization (TARE) is a protracted modality of radiation therapy where radionuclides labeled with Yttrium-90 (90Y) are inserted inside a patient's hepatic artery to treat hepatocellular carcinoma (HCC). While TARE has been shown to be a clinically effective and safe treatment, there is little understanding of the radiobiological relationship between absorbed dose and tissue response, and thus there is no dosimetric standard for treatment planning. The Biologically Effective Dose (BED) formalism, derived from the Linear-Quadratic model of radiobiology, is used to weigh the absorbed dose by the time pattern of delivery. BED is a virtual dose that can …

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Modeling Self-Diffusiophoretic Janus Particles In Fluid, Kausik Das Jan 2023

Modeling Self-Diffusiophoretic Janus Particles In Fluid, Kausik Das

HMC Senior Theses

We explore spherical Janus particles in which a chemical reaction occurs on one face, depleting a substrate in the suspending fluid, while no reaction occurs on the other face. The steady state concentration field is governed by Laplace’s equation with mixed boundary conditions. We use the collocation method to obtain numerical solutions to the equation in spherical coordinates. The asymmetry of the reaction gives rise to a slip velocity that causes the particle to move spontaneously in the fluid through a process known as self-diffusiophoresis. Using the Lorentz reciprocal theorem, we obtain the swimming velocity of the particle. We extend …

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Optical Tweezers: Exerting Force With Light, Gabriella Seifert Jan 2023

Optical Tweezers: Exerting Force With Light, Gabriella Seifert

Scripps Senior Theses

Photons carry momentum. When a tightly-focused beam of photons hit a particle, they transfer some of their momentum to the particle, exerting a force. Optical tweezers take advantage of this phenomenon to trap (or “tweeze”) a spherical bead just after the focus of a diverging laser beam, creating a potential well that pulls in beads. In this thesis, I predict the force exerted on trapped beads and measure the actual force using an optical tweezers setup that I built. To predict the force, I follow the path of all possible rays from a diverging beam incident on a spherical bead …

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Decoherence And Preferred Tensor Product Structures For Systems Of Qubits, Marissa M. Singh Jan 2023

Decoherence And Preferred Tensor Product Structures For Systems Of Qubits, Marissa M. Singh

Pitzer Senior Theses

In recent decades, the program of Decoherence has helped clarify how features of the classical world emerge from Quantum Mechanics. According to Decoherence, the interaction between a system and its environment dynamically selects certain system states — the pointer states — that exhibit predictable, classical behavior while their superpositions rapidly decohere. However, most Decoherence studies to date pre-suppose a preferred division of the world into “system” and “environment”, corresponding to a preferred choice of Tensor Product Structure (TPS) on the Hilbert Space of states. A few previous works have suggested that the existence of a well-defined pointer observable may be …

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Can The Xy+Z Heisenberg Model Be Compressed Using The Yang-Baxter Equation? An Exploration Of The Compression Of Quantum Time Dynamic Circuits Describing Heisenberg Spin Chains, Miriam Caron, Bo Peng Dr., Scott Gould Dr., Kevin Setter Dr., Niranjan Govind Dr. Jan 2023

Can The Xy+Z Heisenberg Model Be Compressed Using The Yang-Baxter Equation? An Exploration Of The Compression Of Quantum Time Dynamic Circuits Describing Heisenberg Spin Chains, Miriam Caron, Bo Peng Dr., Scott Gould Dr., Kevin Setter Dr., Niranjan Govind Dr.

Pitzer Senior Theses

Quantum computing is currently deployed on noisy intermediate-scale quantum (NISQ) devices, which are only able to simulate circuits reliably on shallow depth quantum circuits. A promising problem on near-term quantum computers is quantum time dynamics (QTD). However, QTD circuits grow with increasing time simulations making them difficult to simulate on NISQ devices. This thesis project explores QTD simulations in variations of 1D Heisenberg spin chains with nearest-neighbor and transverse external field interactions with an eye towards studying the dynamics in broader classes of spin models. I first study the quantum Yang-Baxter equation (YBE) and how it has been shown to …

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