Physical Sciences and Mathematics Commons^™

Development And Use Of Lipidomics And Proteomics Methods To Identify And Measure Pro-Survival Metabolic Pathways In Cancer, Monique Merilyn Speirs

Theses and Dissertations

Throughout society’s continual war against cancer, we have attempted pharmacological intervention only to find that tumors develop modes of resistance. It is well known that genetics play an integral role in cancer. Technological advances have greatly improved our ability to study cancer biochemistry beyond the genome by measuring changes in the expression and activity of RNA, proteins, and lipids in experimental models and human patients. As our techniques and technology to perform cancer research progresses, it is becoming more evident that cancer cells develop stress tolerance mechanisms at multiple levels within the central dogma, including altering mRNA expression, enzyme concentrations, …