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Full-Text Articles in Physical Sciences and Mathematics
A Non-Deterministic Deep Learning Based Surrogate For Ice Sheet Modeling, Hannah Jordan
A Non-Deterministic Deep Learning Based Surrogate For Ice Sheet Modeling, Hannah Jordan
Graduate Student Theses, Dissertations, & Professional Papers
Surrogate modeling is a new and expanding field in the world of deep learning, providing a computationally inexpensive way to approximate results from computationally demanding high-fidelity simulations. Ice sheet modeling is one of these computationally expensive models, the model used in this study currently requires between 10 and 20 minutes to complete one simulation. While this process is adequate for certain applications, the ability to use sampling approaches to perform statistical inference becomes infeasible. This issue can be overcome by using a surrogate model to approximate the ice sheet model, bringing the time to produce output down to a tenth …
Ensemble Protein Inference Evaluation, Kyle Lee Lucke
Ensemble Protein Inference Evaluation, Kyle Lee Lucke
Graduate Student Theses, Dissertations, & Professional Papers
The Protein inference problem is becoming an increasingly important tool that aids in the characterization of complex proteomes and analysis of complex protein samples. In bottom-up shotgun proteomics experiments the metrics for evaluation (like AUC and calibration error) are based on an often imperfect target-decoy database. These metrics make the inherent assumption that all of the proteins in the target set are present in the sample being analyzed. In general, this is not the case, they are typically a mix of present and absent proteins. To objectively evaluate inference methods, protein standard datasets are used. These datasets are special in …
Inference Of Surface Velocities From Oblique Time Lapse Photos And Terrestrial Based Lidar At The Helheim Glacier, Franklyn T. Dunbar Ii
Inference Of Surface Velocities From Oblique Time Lapse Photos And Terrestrial Based Lidar At The Helheim Glacier, Franklyn T. Dunbar Ii
Graduate Student Theses, Dissertations, & Professional Papers
Using time dependent observations derived from terrestrial LiDAR and oblique
time-lapse imagery, we demonstrate that a Bayesian approach to glacial motion es-
timation provides a concise way to incorporate multiple data products into a single
motion estimation procedure effectively producing surface velocity estimates with
an associated uncertainty. This approach brings both improved computational effi-
ciency, and greater scalability across observational time-frames when compared to
existing methods. To gauge efficacy, we apply these methods to a set of observa-
tions from the Helheim Glacier, a critical actor in contemporary mass loss trends
observed in the Greenland Ice Sheet. We find that …
K-Mer Analysis Pipeline For Classification Of Dna Sequences From Metagenomic Samples, Russell Kaehler
K-Mer Analysis Pipeline For Classification Of Dna Sequences From Metagenomic Samples, Russell Kaehler
Graduate Student Theses, Dissertations, & Professional Papers
Biological sequence datasets are increasing at a prodigious rate. The volume of data in these datasets surpasses what is observed in many other fields of science. New developments wherein metagenomic DNA from complex bacterial communities is recovered and sequenced are producing a new kind of data known as metagenomic data, which is comprised of DNA fragments from many genomes. Developing a utility to analyze such metagenomic data and predict the sample class from which it originated has many possible implications for ecological and medical applications. Within this document is a description of a series of analytical techniques used to process …