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Physical Sciences and Mathematics Commons™
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Articles 1 - 21 of 21
Full-Text Articles in Physical Sciences and Mathematics
Structure-Activity Relationship Of Anticancer Drug Candidate Quinones, Nadire Özenver, Neslihan Sönmez, Merve Yüzbaşıoğlu Baran, Ayşe Uz, Lütfiye Ömür Demi̇rezer
Structure-Activity Relationship Of Anticancer Drug Candidate Quinones, Nadire Özenver, Neslihan Sönmez, Merve Yüzbaşıoğlu Baran, Ayşe Uz, Lütfiye Ömür Demi̇rezer
Turkish Journal of Chemistry
Breast cancer is one of the most prevalent cancer types worldwide. Chemotherapy is a substantial approach in the management of breast cancer despite the occurrence of chemotherapy-associated side effects and the development of multidrug resistance in cancer cells. At this point, a variety of quinone derivatives may represent potential as possible anticancer drug candidates due to possessing structural similarity towards clinically used anticancer drugs like doxorubicin. Therefore, we investigated the cytotoxic effects of various quinone derivatives with structural diversity towards a variety of breast cancer cells. We further determined their toxicity in healthy cells to evaluate their drug capability potential. …
Comparative Study Of Electrochemical-Based Sensors And Immunosensors In Terms Of Advantageous Features For Detection Of Cancer Biomarkers, Göksu Özçeli̇kay, Ahmet Çeti̇nkaya, Sari̇ye İrem Kaya, Si̇bel Ayşil Özkan
Comparative Study Of Electrochemical-Based Sensors And Immunosensors In Terms Of Advantageous Features For Detection Of Cancer Biomarkers, Göksu Özçeli̇kay, Ahmet Çeti̇nkaya, Sari̇ye İrem Kaya, Si̇bel Ayşil Özkan
Turkish Journal of Chemistry
Cancer, becoming increasingly common globally, has a high mortality rate. Despite the much research on diagnosis and treatment methods, the benefits of technological developments, and newly developed sensor devices, cancer is still one of the leading causes of death worldwide. Early detection using powerful and noninvasive tools could be a future focus for prognosis and treatment follow-up. Therefore, electrochemical biosensors can be a strong choice for the detection of cancer biomarkers (such as alpha-fetoprotein, cytochrome c, prostate-specific antigen, myoglobin, carcinoembryonic antigen, alpha-fetoprotein, a cancer antigen, epidermal growth factor receptor, vascular endothelial growth factor, circulating tumor cell, and breast cancer antigen …
(R1980) Effect Of Climate Change On Brain Tumor, Pardeep Kumar, Sarita Jha, Rajiv Aggarwal, Govind Kumar Jha
(R1980) Effect Of Climate Change On Brain Tumor, Pardeep Kumar, Sarita Jha, Rajiv Aggarwal, Govind Kumar Jha
Applications and Applied Mathematics: An International Journal (AAM)
In this paper, we introduce a new dynamical model addressing the variation in climate condition due the presence of microorganisms. We also introduce a new dynamical model of cancer growth which includes three interactive cell populations with drug free environment, namely tumor cells, healthy host cells, and immune effector cells. In this, we considered the super growth of tumor cells. For the choice of certain parameters, both of the systems exhibit chaotic behavior. The aim of this work is to design the controller to control the chaos and to provide sufficient conditions which achieve synchronization of two non-identical systems, which …
An Axiomatic And Contextual Review Of The Armitage And Doll Model Of Carcinogenesis, W. Zane Billings, Justin Clifton, Josh Hiller, Tommy Meek, Andrew Penland, Wesley Rogers, Gabriella Smokovich, Andrew Velasquez-Berroteran, Eleni Zamagias
An Axiomatic And Contextual Review Of The Armitage And Doll Model Of Carcinogenesis, W. Zane Billings, Justin Clifton, Josh Hiller, Tommy Meek, Andrew Penland, Wesley Rogers, Gabriella Smokovich, Andrew Velasquez-Berroteran, Eleni Zamagias
Spora: A Journal of Biomathematics
In 1954, Armitage and Doll published one of the most influential papers in the history of mathematical epidemiology. However, when one examines the literature one finds that there are in fact at least three distinct mathematical models attributed to the 1954 paper. In this study, we examine this important paper and the mathematical derivation of their model. We find, very surprisingly, that no stochastic process can account for all the assumptions of the model and that many of the models in the literature use a consistent subset of the assumptions used in Armitage and Doll's paper.
Clinical Diagnosis Support With Convolutional Neural Network By Transfer Learning, Spencer Fogleman, Jeremy Otsap, Sangrae Cho
Clinical Diagnosis Support With Convolutional Neural Network By Transfer Learning, Spencer Fogleman, Jeremy Otsap, Sangrae Cho
SMU Data Science Review
Breast cancer is prevalent among women in the United States. Breast cancer screening is standard but requires a radiologist to review screening images to make a diagnosis. Diagnosis through the traditional screening method of mammography currently has an accuracy of about 78% for women of all ages and demographics. A more recent and precise technique called Digital Breast Tomosynthesis (DBT) has shown to be more promising but is less well studied. A machine learning model trained on DBT images has the potential to increase the success of identifying breast cancer and reduce the time it takes to diagnose a patient, …
Personalized Medicine: The Use Of Biomarkers And Molecularly Targeted Therapies For Patient Care And Cancer Intervention, Wafa Asad, Emily Schmitt Lavin
Personalized Medicine: The Use Of Biomarkers And Molecularly Targeted Therapies For Patient Care And Cancer Intervention, Wafa Asad, Emily Schmitt Lavin
Mako: NSU Undergraduate Student Journal
Personalized medicine and targeted therapy have been emerging fields of study for the remediation and inhibition of cancer. Personalized medicine in the treatment of cancer involves using genetic, immune, and proteomic profiling to provide therapeutic options as well as prognostic background for every patient and their tumor’s genetic mutations. Targeted therapies allow researchers and medical personnel alike to determine the appropriate treatment for a patient based on the molecular basis and mechanistic actions of a cancerous tumor. The overall significance of this study was to express how these treatments use biomarkers to pinpoint the location, and severity of the cancer, …
The Single Nucleotide Ss-Arrestin2 Variant, A248t, Resembles Dynamical Properties Of Activated Arrestin, Özge Şensoy
The Single Nucleotide Ss-Arrestin2 Variant, A248t, Resembles Dynamical Properties Of Activated Arrestin, Özge Şensoy
Turkish Journal of Chemistry
ß-arrestins are responsible for termination of G protein-coupled receptor (GPCR)-mediated signaling. Association of single nucleotide variants with onset of crucial diseases has made this protein family hot targets in the field of GPCR-mediated pharmacology. However, impact of these mutations on function of these variants has remained elusive. In this study, structural and dynamical properties of one of ß-arrestin2 (arrestin 3) variants, A248T, which has been identified in some cancer tissue samples, were investigated via molecular dynamics simulations. The results showed that the variant underwent structural rearrangements which are seen in crystal structures of active arrestin. Specifically, the "short helix" unravels …
Synthesis, Cytotoxic Assessment, And Molecular Docking Studies Of2,6-Diaryl-Substituted Pyridine And 3,4- Dihydropyrimidine-2(1h)-One Scaffolds, Zahra Hosseinzadeh, Nima Razzaghi-Asl, Ali Ramazani, Hamideh Aghahosseini, Ali Ramazani
Synthesis, Cytotoxic Assessment, And Molecular Docking Studies Of2,6-Diaryl-Substituted Pyridine And 3,4- Dihydropyrimidine-2(1h)-One Scaffolds, Zahra Hosseinzadeh, Nima Razzaghi-Asl, Ali Ramazani, Hamideh Aghahosseini, Ali Ramazani
Turkish Journal of Chemistry
Cancer is one of the main global health problems. In order to develop novel antitumor agents, we synthesized 3,4-dihydropyrimidine-2(1H)-one (DHPM) and 2,6-diaryl-substituted pyridine derivatives as potential antitumor structures and evaluated their cytotoxic effects against several cancer cell lines. An easy and convenient method is reported for the synthesis of these derivatives, employing cobalt ferrite (CoFe$_{2}$ O$_{4}$ @SiO$_{2}$ -SO$_{3}$ H) magnetic nanoparticles under microwave irradiation and solvent-free conditions. The structural characteristics of the prepared nanocatalyst were investigated by FTIR, XRD, SEM, and TGA techniques. In vitro cytotoxic effects of the synthesized products were assessed against the human breast adenocarcinoma cell line …
Non-Standard Finite Difference Schemes For Investigating Stability Of A Mathematical Model Of Virus Therapy For Cancer, A. R. Yaghoubi, H. S. Najafi
Non-Standard Finite Difference Schemes For Investigating Stability Of A Mathematical Model Of Virus Therapy For Cancer, A. R. Yaghoubi, H. S. Najafi
Applications and Applied Mathematics: An International Journal (AAM)
In this paper, a special case of finite difference method called non-standard finite difference (NSFD) method was studied to compute the numerical solutions of the nonlinear mathematical model of the interaction between tumor cells and oncolytic viruses. The global stability of the equilibrium points of the discrete model is investigated by using the Lyapunov stability theorem. Some conditions were gained for the local asymptotical stability of the equilibrium points of the system. Finally, numerical simulations are carried out to illustrate the main theoretical results. The discrete system is dynamically consistent with its continuous model, it preserves essential properties, such as …
Cancerous Male And Female Gene Expression, Clarissa Farmer, E. Shannon Tass
Cancerous Male And Female Gene Expression, Clarissa Farmer, E. Shannon Tass
Journal of Undergraduate Research
Genetic diagnosing is becoming more popular, as well as more and more accurate. However, many genetic diseases have complex genetic effects and are still not fully understood. Transthyretin Amyloidosis (ATTR; also known as familial or hereditary amyloidosis) is a terminal genetic disease. It is caused by unstable transthyretin proteins that fold improperly, and then deteriorate. The fragmented proteins are deposited outside of the cell and build up in the tissues over time, forming insoluble oligomers. The oligomers continue to grow into Amyloid fibrils, which adversely affect many organs in the body, eventually causing their failure. In order to accurately diagnose, …
Application Of Nanomaterials In The Detection Of Volatile Organic Compounds In Exhaled Breath For Cancer Diagnosis, Wan-Qiao Bai, Xue-Zhi Qiao, Tie Wang
Application Of Nanomaterials In The Detection Of Volatile Organic Compounds In Exhaled Breath For Cancer Diagnosis, Wan-Qiao Bai, Xue-Zhi Qiao, Tie Wang
Journal of Electrochemistry
Volatile organic compounds (VOCs) generated in human body can reflect one’s health state, and numerous diseases are identified by some VOCs biomarkers. More recently, analyses of VOCs biomarkers from exhaled breath have turned into a research frontier worldwide because it offers a noninvasive way for diseases diagnosis. Various kinds of nanomaterials are used to enhance the performance of sensing techniques, and play an essential role in miniaturization detection. In this review, several kinds of nanomaterials (metallic, metal oxide, carbon-based, composites and MOFs-based materials) used in various VOCs detection methods, especially in VOCs sensors are summarized. Learning from the successful utilization …
Minimizing The Perceived Financial Burden Due To Cancer, Hassan Azhar, Zoheb Allam, Gino Varghese, Daniel W. Engels, Sajiny John
Minimizing The Perceived Financial Burden Due To Cancer, Hassan Azhar, Zoheb Allam, Gino Varghese, Daniel W. Engels, Sajiny John
SMU Data Science Review
In this paper, we present a regression model that predicts perceived financial burden that a cancer patient experiences in the treatment and management of the disease. Cancer patients do not fully understand the burden associated with the cost of cancer, and their lack of understanding can increase the difficulties associated with living with the disease, in particular coping with the cost. The relationship between demographic characteristics and financial burden were examined in order to better understand the characteristics of a cancer patient and their burden, while all subsets regression was used to determine the best predictors of financial burden. Age, …
Stock Market Reactions To The Iarc Announcement Linking Red Meat And Processed Meat To Cancer, Scott B. Lehman
Stock Market Reactions To The Iarc Announcement Linking Red Meat And Processed Meat To Cancer, Scott B. Lehman
Journal of Environmental and Resource Economics at Colby
This study investigates how food companies were affected by the International Agency for Research on Cancer’s report that linked processed meat and red meat consumption to increased risk of cancer. The results indicate that neither fast food companies nor meat producers were greatly affected by the announcement in the days immediately following the release.
Autophagy-Mediated Mechanisms Of Chemoresistance In Cancer, David Broadbent, Dr. Joshua Andersen
Autophagy-Mediated Mechanisms Of Chemoresistance In Cancer, David Broadbent, Dr. Joshua Andersen
Journal of Undergraduate Research
The resistance of tumor cells to chemotherapy is a critical problem in the clinic and is a common cause of mortality in cancer. Emerging data suggests that resistance to chemotherapy is caused by a tumor-expressed protein called 14-3-3ζ, yet the mechanism to explain 14-3-3ζ-mediated chemoresistance is not completely understood (1). Rapid growing tumors often outgrow their blood supply resulting in regions of hypoxia (low glucose and oxygen). These cells must adapt or die and those that do adapt often become metastatic and chemoresistant. A recently proposed mechanism by which cancer cells are able to adapt to hypoxia is via autophagy, …
Cancer Risk Analysis By Fuzzy Logic Approach And Performance Status Of The Model, Atinç Yilmaz, Kürşat Ayan
Cancer Risk Analysis By Fuzzy Logic Approach And Performance Status Of The Model, Atinç Yilmaz, Kürşat Ayan
Turkish Journal of Electrical Engineering and Computer Sciences
Cancer is the leading life-threatening disease for people in today's world. Although cancer formation is different for each type of cancer, it has been determined by studies and research that stress also triggers cancer types. Early precaution is very important for people who have not fallen ill yet with a disease like cancer that has a high mortality rate and expensive treatment. With this study, we expound that the possibility of developing such disease may be decreased and people could take measures against it. For the 3 cancer types selected as pilot work by introducing a fuzzy logic model, the …
Progress Towards A Facile Synthesis Of A Gadolinium (Iii) Octabrominated Porphyrin, Tseng Xiong
Progress Towards A Facile Synthesis Of A Gadolinium (Iii) Octabrominated Porphyrin, Tseng Xiong
The Corinthian
Towards preparing porphyrin complexes that combine contrast agent and photodynamic therapy capabilities at tumor sites, the Gd(III) porphyrin derivative of the octabrominated meso-tetrakis(N-methyl-4-pyridyl)porphyrin, GdTMPyPBr8 5+ was synthesized by refluxing Gd(III) ion with H3TMPyPBr8 5+ at pH 7. The metallocomplex was characterized by UV-visible spectroscopy and showed a Soret band shift from 503 nm to 463 nm at pH 7, suggesting that metal insertion of Gd(III) into the core of porphyrin ligand had occurred. However, synthesis of the Gd(III) complex required high temperatures and long reaction times. To circumvent these harsh conditions, the lithium porphyrin derivative was first prepared and subsequently …
Sdre Optimal Control Of Drug Administration In Cancer Treatment, Mehmet İti̇k, Meti̇n Uymaz Salamci̇, Stephen Paul Banks
Sdre Optimal Control Of Drug Administration In Cancer Treatment, Mehmet İti̇k, Meti̇n Uymaz Salamci̇, Stephen Paul Banks
Turkish Journal of Electrical Engineering and Computer Sciences
In this study, we apply State Dependent Riccati Equation (SDRE) based optimal control technique to a nonlinear tumor growth model. The model consists of three biological cells which are normal tissue, tumor and immune cells. The effect of chemotherapy treatment is also included in the model. Chemotherapy administration is considered as a control input to the nonlinear cancer dynamics and the amount of administered drug is determined by using SDRE optimal control. The optimal control is applied to the model in order not only to drive the tumor cells to the healthy equilibrium state but also to minimize the amount …
A Comparison Of Different Methods For Predicting Cancer Mortality Counts At The State Level, Corinne Wilson
A Comparison Of Different Methods For Predicting Cancer Mortality Counts At The State Level, Corinne Wilson
Virginia Journal of Science
Cancer is a major health issue in the United States. Reliable estimates of yearly cancer mortality counts are essential for resourcing and planning. The American Cancer Society has used several methods of forecasting to estimate the future cancer burden and researchers are continually working to develop new methods with improved performance. There have been studies comparing different models for predicting the US cancer mortality counts. This study explores and compares several different models for cancer mortality count predictions at the state level, principally for the state of Virginia. Results of the comparisons appear to show the final improved model to …
Homogeneous Markov Processes For Breast Cancer Analysis, Ricardo Ocaña-Rilola, Emilio Sanchez-Cantalejo, Carmen Martinez-Garcia
Homogeneous Markov Processes For Breast Cancer Analysis, Ricardo Ocaña-Rilola, Emilio Sanchez-Cantalejo, Carmen Martinez-Garcia
Journal of Modern Applied Statistical Methods
Sometimes, the introduction of covariates in stochastic processes is required to study their effect on disease history events. However these types of models increase the complexity of analysis, even for simpler processes, and standard software to analyse stochastic processes is limited. In this paper, a method for fitting homogeneous Markov models with covariates is proposed for analysing breast cancer data. Specific software for this purpose has been implemented.
Perceived Risks Of Emfs And Landowner Compensation, Linda J. Orel
Perceived Risks Of Emfs And Landowner Compensation, Linda J. Orel
RISK: Health, Safety & Environment (1990-2002)
Although public concerns about EMFs may eventually prove groundless, they can nevertheless depress the market value of residential property near powerlines. Ms. Orel argues that the scientific truth, as courts increasingly recognize, should play no role in determining whether or how much landowners should recover.
A Survey Of Residual Cancer Risks Permitted By Health, Safety And Environmental Policy, March Sadowitz, John D. Graham
A Survey Of Residual Cancer Risks Permitted By Health, Safety And Environmental Policy, March Sadowitz, John D. Graham
RISK: Health, Safety & Environment (1990-2002)
The authors describe permitted U.S. residual cancer risks, focusing on numerical levels specifically and implicitly authorized by statute or regulation. They also discuss potential changes.