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Full-Text Articles in Physical Sciences and Mathematics
Magnetic Hyperthermia For Cancer Treatment, Çiğdem Elif Demirci Dönmez, Adem Dönmez
Magnetic Hyperthermia For Cancer Treatment, Çiğdem Elif Demirci Dönmez, Adem Dönmez
Science and Mathematical Science
The obtained results in this study clearly indicates the enhancing effect of polymer coating on hyperthermia efficiency. In a very recent study, the efficiency of the niclosamide-loaded hyperbranched polymerfunctionalized magnetic nanoparticles on mediated hyperthermia and niclosamide (an anticancer drug) bimodel therapy were investigated. The results in this study indicated that polymerfunctionalized nanoparticles showed sufficient temperature gain for magnetic hyperthermia.
Improving Binding Affinity Through Cyclization, Kaylee M. Newcomb, Nicolas Abrigo
Improving Binding Affinity Through Cyclization, Kaylee M. Newcomb, Nicolas Abrigo
Undergraduate Research Posters
Cancer chemotherapy results in systematic damage as the drugs used are also toxic to benign tissue. Sensitizing a cancer cell to therapy by interfering with the DNA repair mechanisms would decrease overall toxicity, as the necessary dosage of chemotherapy drugs would be lowered. The Hartman lab developed a peptide (8.6) that binds with a KD of 1 μM to the C-terminal domain of breast cancer associated protein (BRCA1), blocking homologous recombination. The crystal structure of the peptide shows the tyrosine and threonine residues are close together, suggesting that by cyclizing these positions, the peptide may already be constrained into its …