Physical Sciences and Mathematics Commons^™

Characterization Of A Thermoresponsive Water-Soluble Polymer: Block-Copoly [Ethylene Glycol/Graft-Co (Vinyl Alcohol/Vinyl Caprolactam)], Adebola Margaret Adeleni

MSU Graduate Theses

Thermoresponsive polymers are a class of smart materials that exhibit change in their physical properties with temperature, which make them unique and useful materials in a wide range of biomedical applications. Soluplus®, a thermoresponsive block graft copolymer with poly(vinyl acetate) PVAc and poly(vinyl caprolactam) PVCL block grafted on a poly(ethelyne glycol) PEG backbone in a ratio of 30:57:13 respectively, is marketed by BASF Corporation, it aids in solubilizing and increasing the bioavailability of active Pharmaceutical ingredients in poorly water soluble drugs. In order to elucidate the effect of hydrophobic/hydrophilic balance on thermoresponsive behavior of Soluplus® in water. Soluplus® was hydrolyzed …