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Full-Text Articles in Physical Sciences and Mathematics
Pharmacology Of Veratrum Californicum Alkaloids As Hedgehog Pathway Antagonists, Madison L. Dirks, Owen M. Mcdougal
Pharmacology Of Veratrum Californicum Alkaloids As Hedgehog Pathway Antagonists, Madison L. Dirks, Owen M. Mcdougal
Chemistry and Biochemistry Faculty Publications and Presentations
Veratrum californicum contains steroidal alkaloids that function as inhibitors of hedgehog (Hh) signaling, a pathway involved in the growth and differentiation of cells and normal tissue development. This same Hh pathway is abnormally active for cell proliferation in more than 20 types of cancer. In this current study, alkaloids have been extracted from the root and rhizome of V. californicum, followed by their separation into five fractions using high performance liquid chromatography. Mass spectrometry was used to identify the presence of twenty-five alkaloids, nine more than are commonly cited in literature reports, and the Bruker Compass Data Analysis software …
Veratrum Parviflorum: An Underexplored Source For Bioactive Steroidal Alkaloids, Jared T. Seale, Owen M. Mcdougal
Veratrum Parviflorum: An Underexplored Source For Bioactive Steroidal Alkaloids, Jared T. Seale, Owen M. Mcdougal
Chemistry and Biochemistry Faculty Publications and Presentations
Plants of the Veratrum genus have been used throughout history for their emetic properties, rheumatism, and for the treatment of high blood pressure. However, inadvertent consumption of these plants, which resemble wild ramps, induces life-threatening side effects attributable to an abundance of steroidal alkaloids. Several of the steroidal alkaloids from Veratrum spp. have been investigated for their ability to antagonize the Hedgehog (Hh) signaling pathway, a key pathway for embryonic development and cell proliferation. Uncontrolled activation of this pathway is linked to the development of various cancers; most notably, basal cell carcinoma and acute myeloid leukemia. Additional investigation of Veratrum …
Medicinal History Of North American Veratrum, Christopher M. Chandler, Owen M. Mcdougal
Medicinal History Of North American Veratrum, Christopher M. Chandler, Owen M. Mcdougal
Chemistry and Biochemistry Faculty Publications and Presentations
Plants belonging to the genus Veratrum have been used throughout history for their medicinal properties. During the nineteenth and twentieth centuries, phytochemical investigations revealed a host of steroidal alkaloids in Veratrum species, some of which are potent bioactives. This review discusses Veratrum species that grow in North America with a focus on the medicinal history of these plants and the steroidal alkaloids they contain. While significant reviews have been devoted to singularly describing the plant species within the genus Veratrum (botany), the staggering breadth of alkaloids isolated from these and related plants (phytochemistry), and the intricacies of how the various …