Physical Sciences and Mathematics Commons^™

The Development Of Silica Hydride Stationary Phases For High-Performance Liquid Chromatography From Conception To Commercialization, Maria Matyska-Pesek, Joseph Pesek

Faculty Publications, Chemistry

The development of a stationary phase material for high-performance liquid chromatography based on a surface of silica hydride as opposed to silanols on ordinary silica is discussed including synthetic approaches, characterization, and applications. There are several synthetic approaches available to create a silica hydride surface. Modification of the Si–H moiety on the silica surface can be accomplished through the use of a hydrosilation reaction. Both the intermediate silica hydride and the material modified with an organic moiety can be characterized by a number of spectroscopic as well as a variety of other methods. Further insights into the retention mechanism are …