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Physical Sciences and Mathematics Commons

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Full-Text Articles in Physical Sciences and Mathematics

A Model Of Dendritic Cell Therapy For Melanoma, Lisette G. De Pillis, Angela Gallegos, Ami E. Radunskaya Mar 2013

A Model Of Dendritic Cell Therapy For Melanoma, Lisette G. De Pillis, Angela Gallegos, Ami E. Radunskaya

All HMC Faculty Publications and Research

Dendritic cells are a promising immunotherapy tool for boosting an individual’s antigen-specific immune response to cancer. We develop a mathematical model using differential and delay-differential equations to describe the interactions between dendritic cells, effector-immune cells, and tumor cells. We account for the trafficking of immune cells between lymph, blood, and tumor compartments. Our model reflects experimental results both for dendritic cell trafficking and for immune suppression of tumor growth in mice. In addition, in silico experiments suggest more effective immunotherapy treatment protocols can be achieved by modifying dose location and schedule. A sensitivity analysis of the model reveals which patient-specific …


A Nonlinear Ode Model Of Tumor Growth And Effect Of Immunotherapy And Chemotherapy Treatment In Colorectal Cancer, Hannah P. Savage May 2010

A Nonlinear Ode Model Of Tumor Growth And Effect Of Immunotherapy And Chemotherapy Treatment In Colorectal Cancer, Hannah P. Savage

HMC Senior Theses

Colorectal cancer will kill approximately 50,000 people in the United States this year. Current treatment options, including surgery, chemotherapy, and radiation, are often able to force the cancer into remission, but better treatments are needed to help those who don't respond to current treatments. A new and promising treatment option, monoclonal-antibody therapy, has the potential to help reduce the deaths caused by colorectal cancer, but most monoclonal-antibody drugs are currently still in trial phases, and the variations in the dosing schedule of those currently approved for use have not been heavily explored. We have modified a nonlinear ODE tumor/treatment model …


A Mathematical Tumor Model With Immune Resistance And Drug Therapy: An Optimal Control Approach, Lisette G. De Pillis, Ami E. Radunskaya Jan 2001

A Mathematical Tumor Model With Immune Resistance And Drug Therapy: An Optimal Control Approach, Lisette G. De Pillis, Ami E. Radunskaya

All HMC Faculty Publications and Research

We present a competition model of cancer tumor growth that includes both the immune system response and drug therapy. This is a four-population model that includes tumor cells, host cells, immune cells, and drug interaction. We analyze the stability of the drug-free equilibria with respect to the immune response in order to look for target basins of attraction. One of our goals was to simulate qualitatively the asynchronous tumor-drug interaction known as “Jeffs phenomenon.” The model we develop is successful in generating this asynchronous response behavior. Our other goal was to identify treatment protocols that could improve standard pulsed chemotherapy …