Physical Sciences and Mathematics Commons^™

The Development Of Novel Platforms For The Imaging Of Cancer By Positron Emission Tomography, Brendon E. Cook

Dissertations, Theses, and Capstone Projects

The role of antibody-based imaging of cancer by positron emission tomography (PET) has expanded significantly in recent years and is poised to radically alter the way that cancer is diagnosed and treated. However, one hurdle that remains is the potentially harmful radiation dose that comes from these imaging agents, as the long circulation time of antibodies (days to weeks) necessitates the use of radionuclides with comparable physical half-lives (i.e. ⁸⁹Zr, ¹²⁴I, etc.). One particularly promising solution is the use of the inverse electron demand Diels-Alder (IEDDA) reaction between a 1,2,4,5-tetrazine (Tz) and a trans-cyclooctene (TCO) for pretargeting. …

Fundamental Chemistry Related To The Separations And Coordination Of Actinium-225, Thorium-227, And Technetium-99, Jasmine L. Hatcher

Dissertations, Theses, and Capstone Projects

This work explores the fundamental chemistry of actinium, thorium, and technetium in an effort to develop methodologies which help to address complications specific to each of these elements. Developing fundamental knowledge in inorganic chemistry has the power to meaningfully address a number of real world problems. By using simple systems and experiments like following an electron or changing the solvent system, we are able to gain invaluable information which can be used to address major issues.

Actinium-225 (t_½: 9.92 d) is an alpha-emitting radionuclide with nuclear properties well suited for alpha therapy of malignant tumors. The present global …