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Full-Text Articles in Physical Sciences and Mathematics
Electrochemiluminescence Assay Based On Bipolar Electrode For Bioanalysis, Mei-Sheng Wu, Jing-Juan Xu, Hong-Yuan Chen
Electrochemiluminescence Assay Based On Bipolar Electrode For Bioanalysis, Mei-Sheng Wu, Jing-Juan Xu, Hong-Yuan Chen
Journal of Electrochemistry
Bipolar electrodes (BPEs) are electronic conductors which are usually embedded into microchannels. The potential difference at the BPE/solution interface is obtained by applying a voltage at the two ends of the microchannel. When it reaches a critical value, the redox reaction takes place at both poles of the BPE simultaneously. Compared with other detection methods, the electrochemiluminescence (ECL) platform based on BPE possesses the advantages of concentration enrichment, high sensitivity, low cost, portable sensor system, no need for a light source, which is quite suitable for bioanalysis. This paper reviews the ECL-BPE strategy for bioanalysis and proposes the future research …
Electrochemiluminescence Biosensors Based On The Signal Amplification Of Co-Reactants, Hai-Jun Wang, Li-Juan Xiao, Ying He, Xin-Ya Jiang, Ya-Li Yuan, Ying Zhuo, Ya-Qin Chai, Ruo Yuan
Electrochemiluminescence Biosensors Based On The Signal Amplification Of Co-Reactants, Hai-Jun Wang, Li-Juan Xiao, Ying He, Xin-Ya Jiang, Ya-Li Yuan, Ying Zhuo, Ya-Qin Chai, Ruo Yuan
Journal of Electrochemistry
Using co-reactants to enhance the luminous efficiency of luminophores is a common, convenient and effective method in the construction of the electrochemiluminescence (ECL) biosensors. However, the different methods of introducing co-reactants in the construction of the ECL biosensors will bring different amplification effects. In this review, several signal amplification methods through co-reactants are summarized: 1) Adding the co-reactants directly into the detection solution; 2) Immobilizing the co-reactants onto the electrode surface; 3) Using enzymatic reaction to generate co-reactants in situ around the electrode surface. And then, the outlook of the ECL signal amplification strategy is proposed on those bases.