Physical Sciences and Mathematics Commons^™

Reducing Opioid Use Disorder And Overdose Deaths In The United States: A Dynamic Modeling Analysis, Erin J. Stringfellow, Tse Yang Lim, Keith Humphreys, Catherine Digennero, Celia Stafford, Elizabeth Beaulieu, Jack Homer, Wayne Wakeland, Multiple Additional Authors

Systems Science Faculty Publications and Presentations

Opioid overdose deaths remain a major public health crisis. We used a system dynamics simulation model of the U.S. opioid-using population age 12 and older to explore the impacts of 11 strategies on the prevalence of opioid use disorder (OUD) and fatal opioid overdoses from 2022 to 2032. These strategies spanned opioid misuse and OUD prevention, buprenorphine capacity, recovery support, and overdose harm reduction. By 2032, three strategies saved the most lives: (i) reducing the risk of opioid overdose involving fentanyl use, which may be achieved through fentanyl-focused harm reduction services; (ii) increasing naloxone distribution to people who use opioids; …