Physical Sciences and Mathematics Commons^™

Observational Studies In Group Testing And Potential Applications., Alexander Christopher Noll

Electronic Theses and Dissertations

The use of group testing to identify individuals with targeted outcomes in a population can greatly improve the efficiency, speed, and cost effectiveness of testing a population for an outcome, or at least for identifying the prevalence of an outcome in a population. The implementation of causal inference techniques can provide the basis for an observational study that would allow an investigator to gather estimates for treatment effectiveness if group testing was conducted on the population in a certain way. This thesis examines a simulation of the above outlined principles in order to demonstrate a potential application for determining treatment …

Statistical Methods For Nonlinear Dynamic Models With Measurement Error Using The Ricker Model, David Joseph Resendes

Open Access Dissertations

In ecological population management, years of animal counts are fit to nonlinear, dynamic models (e.g. the Ricker model) because the values of the parameters are of interest. The yearly counts are subject to measurement error, which inevitably leads to biased estimates and adversely affects inference if ignored. In the literature, often convenient distribution assumptions are imposed, readily available estimated measurement error variances are not utilized, or the measurement error is ignored entirely. In this thesis, ways to estimate the parameters of the Ricker model and perform inference while accounting for measurement error are investigated where distribution assumptions are minimized and …

Weighted Scores Method For Regression Models With Dependent Data, Aristidis K. Nikoloulopoulos, Harry Joe, N. Rao Chaganty

Mathematics & Statistics Faculty Publications

There are copula-based statistical models in the literature for regression with dependent data such as clustered and longitudinal overdispersed counts, for which parameter estimation and inference are straightforward. For situations where the main interest is in the regression and other univariate parameters and not the dependence, we propose a "weighted scores method", which is based on weighting score functions of the univariate margins. The weight matrices are obtained initially fitting a discretized multivariate normal distribution, which admits a wide range of dependence. The general methodology is applied to negative binomial regression models. Asymptotic and small-sample efficiency calculations show that our …

Modeling And Analysis Of Repeated Ordinal Data Using Copula Based Likelihoods And Estimating Equation Methods, Raghavendra Rao Kurada

Mathematics & Statistics Theses & Dissertations

Repeated or longitudinal ordinal data occur in many fields such as biology, epidemiology, and finance. These data normally are analyzed using both likelihood and non-likelihood methods. The first part of this dissertation discusses the multivariate ordered probit model which is a likelihood method based on latent variables. We show that this latent variable model belong to a very general class of Copula models. We use the copula representation for the multivariate ordered probit model to obtain maximum likelihood estimates of the parameters. We apply the methodology in the analysis of real life data examples.

Though likelihood methods are preferable, there …

Efficient Unbiased Estimating Equations For Analyzing Structured Correlation Matrices, Yihao Deng

Mathematics & Statistics Theses & Dissertations

Analysis of dependent continuous and discrete data has become an active area of research. For normal data, correlations fully quantify the dependence. And historically, maximum likelihood method has been very successful to estimate the correlations and unbiased estimating equation approach has become a popular alternative when there may be a departure from normality. In this thesis we show that the optimal unbiased estimating equation coincides with the likelihood equations for normal data. We then introduce a general class of weighted unbiased estimating equations to estimate parameters in a structured correlation matrix. We derive expressions for asymptotic covariance of the estimates, …

Marginal Regression Modeling Under Irregular, Biased Sampling, Petra Buzkova, Thomas Lumley

UW Biostatistics Working Paper Series

In longitudinal studies observations are often obtained at continuous subject-specific times. Frequently the availability of outcome data may be related to the outcome measure or other covariates that are related to the outcome measure. Under such biased sampling designs unadjusted regression analysis yield biased estimates. Building on the work of Lin & Ying (2001) that integrates counting processes techniques with longitudinal data settings we propose a class of estimators that can handle biased sampling. We call those estimators ``inverse--intensity--rate--ratio--weighted'' (IIRR) estimators. Of major focus is a mean--response model where we examine the marginal effect of the covariate X at time …

Longitudinal Data Analysis For Generalized Linear Models Under Irregular, Biased Sampling: Situations With Follow-Up Dependent On Outcome Or Auxiliary Outcome-Related Variables, Petra Buzkova, Thomas Lumley

UW Biostatistics Working Paper Series

In longitudinal studies, observations are often obtained at subject-specific observation times. Those times can be continuous times, not at a set of prespecified times. Frequently the observation times may be related to the outcome measure or other auxiliary variables that are related to the outcome measure but undesirable to condition upon in the regression model for outcome. Regression analysis unadjusted for such sampling designs yield biased estimates. Based on estimating equations, we propose a class of estimators in generalized linear regression models that can handle biased sampling under continuous observation times. We call those estimators ``inverse--intensity rate--ratio--weighted'' (IIRR) estimators. The …

Semiparametric Loglinear Regression For Longitudinal Measurements Subject To Irregular, Biased Follow-Up, Petra Buzkova, Thomas Lumley

UW Biostatistics Working Paper Series

We propose a method for analysis of loglinear regression models for longitudinal data that are subject to continuous and irregular follow-up. Frequently, if the follow-up is irregular, the availability of outcome data may be related to the outcome measure or other covariates that are related to the outcome measure. Under such biased sampling designs unadjusted regression analysis yield biased estimates. We examine the marginal association of the covariates X at time t and the logarithm of the mean of response Y at time t. We focus on semiparametric regression with unspecified baseline function of time. To predict the follow-up times …

Modeling Incomplete Longitudinal Data, Hakan Demirtas

Journal of Modern Applied Statistical Methods

This article presents a review of popular parametric, semiparametric and ad-hoc approaches for analyzing incomplete longitudinal data.

Overlap Bias In The Case-Crossover Design, With Application To Air Pollution Exposures, Holly Janes, Lianne Sheppard, Thomas Lumley

UW Biostatistics Working Paper Series

The case-crossover design uses cases only, and compares exposures just prior to the event times to exposures at comparable control, or “referent” times, in order to assess the effect of short-term exposure on the risk of a rare event. It has commonly been used to study the effect of air pollution on the risk of various adverse health events. Proper selection of referents is crucial, especially with air pollution exposures, which are shared, highly seasonal, and often have a long term time trend. Hence, careful referent selection is important to control for time-varying confounders, and in order to ensure that …