Open Access. Powered by Scholars. Published by Universities.®

Physical Sciences and Mathematics Commons™

Open Access. Powered by Scholars. Published by Universities.®

Statistics and Probability

2010

Microarray

Articles 1 - 2 of 2

Full-Text Articles in Physical Sciences and Mathematics

Survival Analysis Of Microarray Data With Microarray Measurement Subject To Measurement Error, Juan Xiong Nov 2010

Survival Analysis Of Microarray Data With Microarray Measurement Subject To Measurement Error, Juan Xiong

Electronic Thesis and Dissertation Repository

Microarray technology is essentially a measurement tool for measuring expressions of genes, and this measurement is subject to measurement error. Gene expressions could be employed as predictors for patient survival, and the measurement error involved in the gene expression is often ignored in the analysis of microarray data in the literature. Efforts are needed to establish statistical method for analyzing microarray data without ignoring the error in gene expression. A typical microarray data set has a large number of genes far exceeding the sample size. Proper selection of survival relevant genes contributes to an accurate prediction model. We study the …

Go to article

A Mixture Model Based Approach For Estimating The Fdr In Replicated Microarray Data, Shuo Jiao, Shunpu Zhang Mar 2010

A Mixture Model Based Approach For Estimating The Fdr In Replicated Microarray Data, Shuo Jiao, Shunpu Zhang

Shuo Jiao

One of the mostly used methods for estimating the false discovery rate (FDR) is the permutation based method. The permutation based method has the well-known granularity problem due to the discrete nature of the permuted null scores. The granularity problem may produce very unstable FDR estimates. Such instability may cause scientists to over- or under-estimate the number of false positives among the genes declared as significant, and hence result in inaccurate interpretation of biological data. In this paper, we propose a new model based method as an improvement of the permutation based FDR estimation method of SAM [1] The new …

Go to article