Physical Sciences and Mathematics Commons^™

Bayesian Variable Selection Methods For Genome-Wide Association Studies With Categorical Phenotypes, Benazir Rowe

UNLV Theses, Dissertations, Professional Papers, and Capstones

Genome-wide association studies (GWAS) attempt to find the associations between genetic markers and studied traits (phenotypes). The problem of GWAS is complex and various methods have been developed to approach it. One of such methods is Bayesian variable selection (BVS). We describe the BVS methods in detail and demonstrate the ability of BVS method Posterior Inference via Model Averaging and Subset Selection (piMASS) to improve the power of detecting phenotype-associated genetic loci, potentially leading to new discoveries from existing data without increasing the sample size.

We present several ways to improve and extend the applicability of piMASS for GWAS. The …

Bayesian Variable Selection And Post-Selection Inference, Qiyiwen Zhang

Arts & Sciences Electronic Theses and Dissertations

In this dissertation, we first develop a novel perspective to compare Bayesian variable selection procedures in terms of their selection criteria as well as their finite-sample properties. Secondly, we investigate Bayesian post-selection inference in two types of selection problems: linear regression and population selection. We will demonstrate that both inference problems are susceptible to selection effects since the selection procedure is data-dependent. Before comparing Bayesian variable selection procedures, we first classify the current Bayesian variable selection procedures into two classes: those with selection criteria defined on the space of candidate models, and those with selection criteria not explicitly formulated on …