Physical Sciences and Mathematics Commons^™

Topics In Logistic Regression Analysis, Zhiheng Xie

Theses and Dissertations--Statistics

Discrete-time Markov chains have been used to analyze the transition of subjects from intact cognition to dementia with mild cognitive impairment and global impairment as intervening transient states, and death as competing risk. A multinomial logistic regression model is used to estimate the probability distribution in each row of the one-step transition matrix that correspond to the transient states. We investigate some goodness of fit tests for a multinomial distribution with covariates to assess the fit of this model to the data. We propose a modified chi-square test statistic and a score test statistic for the multinomial assumption in each …

Multi-State Models For Interval Censored Data With Competing Risk, Shaoceng Wei

Theses and Dissertations--Statistics

Multi-state models are often used to evaluate the effect of death as a competing event to the development of dementia in a longitudinal study of the cognitive status of elderly subjects. In this dissertation, both multi-state Markov model and semi-Markov model are used to characterize the flow of subjects from intact cognition to dementia with mild cognitive impairment and global impairment as intervening transient, cognitive states and death as a competing risk.

Firstly, a multi-state Markov model with three transient states: intact cognition, mild cognitive impairment (M.C.I.) and global impairment (G.I.) and one absorbing state: dementia is used to model …