Physical Sciences and Mathematics Commons^™

Statistical Methods And Experimental Design For Inference Regarding Dose And/Or Interaction Thresholds Along A Fixed-Ratio Ray, Sharon Dziuba Yeatts

Theses and Dissertations

An alternative to the full factorial design, the ray design is appropriate for investigating a mixture of c chemicals, which are present according to a fixed mixing ratio, called the mixture ray. Using single chemical and mixture ray data, we can investigate interaction among the chemicals in a particular mixture. Statistical models have been used to describe the dose-response relationship of the single agents and the mixture; additivity is tested through the significance of model parameters associated with the coincidence of the additivity and mixture models.It is often assumed that a chemical or mixture must be administered above an unknown …