Physical Sciences and Mathematics Commons^™

Statistical Methods To Study Transposon Sequencing Data: Nonparametric Bayesian Models With Sampling Algorithms, Shai He

Doctoral Dissertations

As the development of Next Generation Sequencing(NGS) technology, researchers can easily obtain data from millions of cells( bulk samples) or just collecting data from a single cell. However, while bulk samples can capture broad changes, it may risk providing an average measurement that is not representative of the genetic state of any individual cell. While single-cell experiments can capture the genetic state of the individual cell, a single cell sample can increase uncertainty, sampling enough cells to gain a representative sample of population is expensive. Therefore, there is a need to integrate information from both bulk and single-cell data to …