Physical Sciences and Mathematics Commons^™

Multiple Imputation For The Comparison Of Two Screening Tests In Two-Phase Alzheimer Studies, Ofer Harel, Xiao-Hua Zhou

UW Biostatistics Working Paper Series

Two-phase designs are common in epidemiological studies of dementia, and especially in Alzheimer research. In the first phase, all subjects are screened using a common screening test(s), while in the second phase, only a subset of these subjects is tested using a more definitive verification assessment, i.e. golden standard test. When comparing the accuracy of two screening tests in a two-phase study of dementia, inferences are commonly made using only the verified sample. It is well documented that in that case, there is a risk for bias, called verification bias. When the two screening tests have only two values (e.g. …