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Power Calculation For Cross-Sectional Stepped-Wedge Cluster Randomized Trials With Binary Outcomes, Linda J. Harrison, Rui Wang
Power Calculation For Cross-Sectional Stepped-Wedge Cluster Randomized Trials With Binary Outcomes, Linda J. Harrison, Rui Wang
Harvard University Biostatistics Working Paper Series
Power calculation for stepped-wedge cluster randomized trials (SW-CRTs) presents unique challenges, beyond those of standard cluster randomized trials (CRTs), due to the need to consider temporal within cluster correlations and background period effects. To date, power calculation methods specific to SW-CRTs have primarily been developed under a linear model. When the outcome is binary, the use of a linear model corresponds to assessing a prevalence difference; yet trial analysis often employs a non-linear link function. We assess power for cross-sectional SW-CRTs under a logistic model fitted by generalized estimating equations. Firstly, under an exchangeable correlation structure, we show the power …