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Full-Text Articles in Physical Sciences and Mathematics
Sample Size Calculation And Power Analysis Of Time-Averaged Difference, Honghu Liu, Tongtong Wu
Sample Size Calculation And Power Analysis Of Time-Averaged Difference, Honghu Liu, Tongtong Wu
Journal of Modern Applied Statistical Methods
Little research has been done on sample size and power analysis under repeated measures design. With detailed derivation, we have shown sample size calculation and power analysis equations for timeaveraged difference to allow unequal sample sizes between two groups for both continuous and binary measures and explored the relative importance of number of unique subjects and number of repeated measurements within each subject on statistical power through simulation.
On The Power Function Of Bayesian Tests With Application To Design Of Clinical Trials: The Fixed-Sample Case, Lyle Broemeling, Dongfeng Wu
On The Power Function Of Bayesian Tests With Application To Design Of Clinical Trials: The Fixed-Sample Case, Lyle Broemeling, Dongfeng Wu
Journal of Modern Applied Statistical Methods
Using a Bayesian approach to clinical trial design is becoming more common. For example, at the MD Anderson Cancer Center, Bayesian techniques are routinely employed in the design and analysis of Phase I and II trials. It is important that the operating characteristics of these procedures be determined as part of the process when establishing a stopping rule for a clinical trial. This study determines the power function for some common fixed-sample procedures in hypothesis testing, namely the one and two-sample tests involving the binomial and normal distributions. Also considered is a Bayesian test for multi-response (response and toxicity) in …