Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Publication
Articles 1 - 2 of 2
Full-Text Articles in Physical Sciences and Mathematics
Aspects Of Stochastic Geometric Mechanics In Molecular Biophysics, David Frost
Aspects Of Stochastic Geometric Mechanics In Molecular Biophysics, David Frost
All Dissertations
In confocal single-molecule FRET experiments, the joint distribution of FRET efficiency and donor lifetime distribution can reveal underlying molecular conformational dynamics via deviation from their theoretical Forster relationship. This shift is referred to as a dynamic shift. In this study, we investigate the influence of the free energy landscape in protein conformational dynamics on the dynamic shift by simulation of the associated continuum reaction coordinate Langevin dynamics, yielding a deeper understanding of the dynamic and structural information in the joint FRET efficiency and donor lifetime distribution. We develop novel Langevin models for the dye linker dynamics, including rotational dynamics, based …
Geometry, Growth And Pattern Formation In Thin Elastic Structures, Salem Al-Mosleh
Geometry, Growth And Pattern Formation In Thin Elastic Structures, Salem Al-Mosleh
Doctoral Dissertations
Thin shells are abundant in nature and industry, from atomic to planetary scales. The mechanical behavior of a thin shell depends crucially on its geometry and embedding in 3 dimensions (3D). In fact, the behavior of extremely thin shells becomes scale independent and only depends on geometry. That is why the crumpling of graphene will have similarities to the crumpling of paper. In this thesis, we start by discussing the static behavior of thin shells, highlighting the role of asymptotic curves (curves with zero normal curvature) in determining the possible deformations and in controlling the folding patterns. In particular, we …