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Full-Text Articles in Physical Sciences and Mathematics
Fluorescence Intensity And Lifetime Imaging Of Free And Micellar-Encapsulated Doxorubicin In Living Cells, X Dai, Zhilian Yue, M E Eccleston, J Swartling, N K H Slater, C F Kaminski
Fluorescence Intensity And Lifetime Imaging Of Free And Micellar-Encapsulated Doxorubicin In Living Cells, X Dai, Zhilian Yue, M E Eccleston, J Swartling, N K H Slater, C F Kaminski
Faculty of Science - Papers (Archive)
Frequency domain fluorescence lifetime imaging microscopy (FLIM) has been used in combination with laser scanning confocal microscopy to study the cellular uptake behavior of the antitumor drug doxorubicin (DOX) and micellar-encapsulated DOX (PLyAd-DOX). The endocytosis uptake process of PLyAd-DOX was monitored over 72 hours using confocal microscopy, with a maximum fluorescence recorded at incubation periods around 24 hours. The micellar structure was not found to release the encapsulated DOX during the time course of imaging. FLIM revealed single lifetime distributions of PLyAd-DOX during accumulation in the cytoplasm. The free DOX in contrast was observed both in the cytoplasm and the …
Free Radicals Run In Lizard Families, Mark Wilson, Mats Olsson, Tobias Uller, Caroline Isaksson, Beth Mott, Mo Healey, Wanger Thomas
Free Radicals Run In Lizard Families, Mark Wilson, Mats Olsson, Tobias Uller, Caroline Isaksson, Beth Mott, Mo Healey, Wanger Thomas
Mark R Wilson
No abstract provided.