Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Physical Sciences and Mathematics
Intranasal Vaccination With Streptococcal Fibronectin Binding Protein Sfb1 Fails To Prevent Growth And Dissemination Of Streptococcus Pyogenes In A Murine Skin Infection Model, Jason D. Mcarthur, E. Medina, J. Chin, B. J. Currie, K. S. Sriprakash, S. R. Talay, G. S. Chhatwal, Mark J. Walker
Intranasal Vaccination With Streptococcal Fibronectin Binding Protein Sfb1 Fails To Prevent Growth And Dissemination Of Streptococcus Pyogenes In A Murine Skin Infection Model, Jason D. Mcarthur, E. Medina, J. Chin, B. J. Currie, K. S. Sriprakash, S. R. Talay, G. S. Chhatwal, Mark J. Walker
Faculty of Science - Papers (Archive)
Fibronectin binding protein F1 (Sfb1) of Streptococcus pyogenes (group A streptococcus [GAS]) is a well-characterized adhesin that has been shown to induce protection in mice against a lethal intranasal GAS challenge after intranasal immunization with cholera toxin B subunit (CTB) as adjuvant. With a murine skin infection model, we have shown that Sfb1/CTB vaccination neither elicits opsonizing antibodies nor prevents systemic bacterial growth and dissemination to internal organs after a subcutaneous GAS challenge. These results indicate that an Sfb1-based vaccine should be complemented with additional protective antigens in order to be used in areas such as the tropical north of …
Two Distinct Genotypes Of Prtf2, Encoding A Fibronectin Binding Protein, And The Evolution Of The Gene Family In Streptococcus Pyogenes, V. Ramachandran, Jason D. Mcarthur, C. E. Behm, C. Gutzeit, M. Dowton, P. K. Fagan, R. Towers, B. J. Currie, K. S. Sriprakash, Mark J. Walker
Two Distinct Genotypes Of Prtf2, Encoding A Fibronectin Binding Protein, And The Evolution Of The Gene Family In Streptococcus Pyogenes, V. Ramachandran, Jason D. Mcarthur, C. E. Behm, C. Gutzeit, M. Dowton, P. K. Fagan, R. Towers, B. J. Currie, K. S. Sriprakash, Mark J. Walker
Faculty of Science - Papers (Archive)
The group A Streptococcus (GAS) is an important pathogen responsible for a wide range of human diseases. Fibronectin binding proteins (FBPs) play important role in promoting GAS adherence and invasion of host cells. The gene prtF2 encodes a FBP and is contained in approximately 60% of GAS strains. In the present study we have examined 51 prtF2-positive GAS strains isolated from the Northern Territory of Australia and describe two genotypes of prtF2, which are mutually exclusive. Both genotypes have been previously identified in the literature as pfbp and fbaB. We show these genotypes map to the same chromosomal location within …