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Full-Text Articles in Physical Sciences and Mathematics

Why Match In Individually And Cluster Randomized Trials?, Laura Balzer, Maya Petersen, Mark Van Der Laan Apr 2012

Why Match In Individually And Cluster Randomized Trials?, Laura Balzer, Maya Petersen, Mark Van Der Laan

Laura B. Balzer

The decision to match individuals or clusters in randomized trials is motivated by both practical and statistical concerns. Matching protects against chance imbalances in baseline covariate distributions and is thereby thought to improve study credibility. Matching is also implemented to increase study power. Analogue to Rose and van der Laan (2009), this article investigates the asymptotic efficiency of pair-matching individuals or clusters relative to not matching in randomized trials. We focus on estimating the average treatment effect. We use the efficient influence curve to understand the information provided by each design for estimation of the target causal parameter. Our approach …


Prognosis Of Acute Myocardial Infarction Complicated By Complete Heart Block (The Worcester Heart Attack Study), Robert Goldberg, Juan Zevallos, Jorge Yarzebski, Joseph Alpert, Joel Gore, Z. Chen, James Dalen Jul 2010

Prognosis Of Acute Myocardial Infarction Complicated By Complete Heart Block (The Worcester Heart Attack Study), Robert Goldberg, Juan Zevallos, Jorge Yarzebski, Joseph Alpert, Joel Gore, Z. Chen, James Dalen

Jorge L. Yarzebski

As part of a community-based study of patients hospitalized with acute myocardial infarction (AMI) in the Worcester, Massachusetts, metropolitan area, changes over time in the incidence rates of complete heart block (CHB) complicating AMI, and the prognostic impact of CHB on the in-hospital and long-term survival of these patients were examined. In all, 4,762 patients with validated AMI hospitalized at 16 hospitals in the Worcester metropolitan area during 1975, 1978, 1981, 1984, 1986 and 1988 constituted the study sample. The incidence rates of CHB complicating AMI remained relatively stable at 5.8% over the 13-year (1975 to 1988) period studied. The …


Long-Term Trends (1986-2003) In The Use Of Coronary Reperfusion Strategies In Patients Hospitalized With Acute Myocardial Infarction In Central Massachusetts, Robert J. Goldberg, Frederick A. Spencer, Joseph Okolo, Darleen M. Lessard, Jorge L. Yarzebski, Joel M. Gore Jul 2010

Long-Term Trends (1986-2003) In The Use Of Coronary Reperfusion Strategies In Patients Hospitalized With Acute Myocardial Infarction In Central Massachusetts, Robert J. Goldberg, Frederick A. Spencer, Joseph Okolo, Darleen M. Lessard, Jorge L. Yarzebski, Joel M. Gore

Jorge L. Yarzebski

BACKGROUND: The objectives of our study were to examine long-term (1986-2003) trends in the use of percutaneous coronary interventions (PCI) and thrombolytic therapy in the management of patients hospitalized at all Central Massachusetts medical centers with acute myocardial infarction (AMI). Our secondary study goal was to examine factors associated with use of these coronary reperfusion strategies. Limited contemporary data are available about changing trends in the use of coronary reperfusion strategies, particularly from a population-based perspective. METHODS: The sample consisted of 9422 greater Worcester (MA) residents hospitalized with AMI at all metropolitan Worcester medical centers in 10 annual periods between …


A Community-Wide Perspective Of Gender Differences And Temporal Trends In The Use Of Diagnostic And Revascularization Procedures For Acute Myocardial Infarction, David Chiriboga, Jorge Yarzebski, Robert Goldberg, Z. Chen, Jerry Gurwitz, Joel Gore, Joseph Alpert, James Dalen Jul 2010

A Community-Wide Perspective Of Gender Differences And Temporal Trends In The Use Of Diagnostic And Revascularization Procedures For Acute Myocardial Infarction, David Chiriboga, Jorge Yarzebski, Robert Goldberg, Z. Chen, Jerry Gurwitz, Joel Gore, Joseph Alpert, James Dalen

Jorge L. Yarzebski

This study compares the overall use, as well as temporal trends, of various diagnostic and revascularization procedures for acute myocardial infarction (AMI) in men and women. The study sample comprised a total of 2,924 men and 1,838 women with validated AMI admitted to any of the 16 teaching and community hospitals in the Worcester, Massachusetts, metropolitan area during 1975, 1978, 1981, 1984, 1986 and 1988. During the period under study there was a significant increase in use of each of the examined procedures during hospitalization for AMI in both men and women. Increasing use of multiple procedures was also seen …


Temporal Trends And Factors Associated With Extent Of Delay To Hospital Arrival In Patients With Acute Myocardial Infarction: The Worcester Heart Attack Study, Jorge Yarzebski, Robert Goldberg, Joel Gore, Joseph Alpert Jul 2010

Temporal Trends And Factors Associated With Extent Of Delay To Hospital Arrival In Patients With Acute Myocardial Infarction: The Worcester Heart Attack Study, Jorge Yarzebski, Robert Goldberg, Joel Gore, Joseph Alpert

Jorge L. Yarzebski

Factors associated with delay to hospital arrival after the onset of symptoms suggestive of acute myocardial infarction (AMI) were examined in the late 1960s and 1970s, but recent data concerning these characteristics are limited. The purpose of the present study was to examine overall and temporal distributions of the extent of patients' delay from the time of onset of AMI symptoms to hospital arrival and factors associated with delay in seeking medical care from a multihospital, population-based perspective. Review of medical records was undertaken of patients hospitalized with a discharge diagnosis of AMI in 16 teaching and community hospitals in …


Patient Delay And Receipt Of Thrombolytic Therapy Among Patients With Acute Myocardial Infarction From A Community-Wide Perspective, Robert Goldberg, Jerry Gurwitz, Jorge Yarzebski, J. Landon, Joel Gore, Joseph Alpert, P. Dalen, James Dalen Jul 2010

Patient Delay And Receipt Of Thrombolytic Therapy Among Patients With Acute Myocardial Infarction From A Community-Wide Perspective, Robert Goldberg, Jerry Gurwitz, Jorge Yarzebski, J. Landon, Joel Gore, Joseph Alpert, P. Dalen, James Dalen

Jorge L. Yarzebski

The duration of patient delay from the time of onset of symptoms of acute myocardial infarction (AMI) to hospital presentation, and the relation of delay time and various patient characteristics to receipt of thrombolytic therapy were examined as part of a community-based study of patients hospitalized with AMI in the Worcester, Massachusetts, metropolitan area. In all, 800 patients with validated AMI hospitalized at 16 hospitals in the Worcester metropolitan area in 1986 and 1988 constituted the study sample. Patients delayed on average 4 hours between noting symptoms suggestive of AMI and presenting to area-wide emergency departments with no significant change …


Reframing Global Health & Environmental Issues In The 21st Century, Nat Quansah Jul 2008

Reframing Global Health & Environmental Issues In The 21st Century, Nat Quansah

Nat Quansah

No abstract provided.


Raokandro Malagasy (Medicinal Plants Of Madagascar), Nat Quansah Dec 2006

Raokandro Malagasy (Medicinal Plants Of Madagascar), Nat Quansah

Nat Quansah

No abstract provided.


Traditional Medicine And Traditional Music In Madagascar, Nat Quansah Oct 2006

Traditional Medicine And Traditional Music In Madagascar, Nat Quansah

Nat Quansah

No abstract provided.


Fahasalamana Sy Ny Tontolo Iainana (Health & Environment), Nat Quansah May 2006

Fahasalamana Sy Ny Tontolo Iainana (Health & Environment), Nat Quansah

Nat Quansah

No abstract provided.


“Pour En Savoir Plus A Propos Des Plantes Médicinales.” Quinzaine Scientifique : Exposition Sur La Célébration De L’Année De La Science, Nat Quansah Apr 2006

“Pour En Savoir Plus A Propos Des Plantes Médicinales.” Quinzaine Scientifique : Exposition Sur La Célébration De L’Année De La Science, Nat Quansah

Nat Quansah

No abstract provided.


Les Plantes Médicinales Et L’Homme, Nat Quansah Apr 2006

Les Plantes Médicinales Et L’Homme, Nat Quansah

Nat Quansah

No abstract provided.


Global Challenges Show, Nat Quansah Feb 2003

Global Challenges Show, Nat Quansah

Nat Quansah

No abstract provided.


Space Ship Earth – Clinic In Forest, Nat Quansah Dec 2002

Space Ship Earth – Clinic In Forest, Nat Quansah

Nat Quansah

No abstract provided.


‘A View From Johannesburg.’ Daily Reports On The World Summit On Sustainable Development, Nat Quansah Aug 2002

‘A View From Johannesburg.’ Daily Reports On The World Summit On Sustainable Development, Nat Quansah

Nat Quansah

No abstract provided.


Role Of Wireless Technology In Meeting Global Health Care Needs., Nat Quansah Aug 2001

Role Of Wireless Technology In Meeting Global Health Care Needs., Nat Quansah

Nat Quansah

No abstract provided.


Trade In Medicinal Plants: The Need For It To Be Carried Out Based On The Principle Of Conservation, Nat Quansah Jan 1998

Trade In Medicinal Plants: The Need For It To Be Carried Out Based On The Principle Of Conservation, Nat Quansah

Nat Quansah

No abstract provided.


Integrated Health Care Development., Nat Quansah Aug 1995

Integrated Health Care Development., Nat Quansah

Nat Quansah

No abstract provided.


Saving The Jungles Of Madagascar, Nat Quansah Jun 1995

Saving The Jungles Of Madagascar, Nat Quansah

Nat Quansah

No abstract provided.


Integrated Health Care System, Nat Quansah Aug 1994

Integrated Health Care System, Nat Quansah

Nat Quansah

No abstract provided.


Outlook: Madagascar, Nat Quansah Mar 1994

Outlook: Madagascar, Nat Quansah

Nat Quansah

No abstract provided.


Africa Features: Madagascar, Wild Drugstore, Nat Quansah Aug 1993

Africa Features: Madagascar, Wild Drugstore, Nat Quansah

Nat Quansah

No abstract provided.


Ethno-Botany. Field Notes Nature Documentaries, Nat Quansah Aug 1993

Ethno-Botany. Field Notes Nature Documentaries, Nat Quansah

Nat Quansah

No abstract provided.


Building Madagascar’S Capacity In Medicinal Plants Research: Training In Ethno-Pharmacology And Phytochemistry, Nat Quansah Apr 1993

Building Madagascar’S Capacity In Medicinal Plants Research: Training In Ethno-Pharmacology And Phytochemistry, Nat Quansah

Nat Quansah

No abstract provided.


Madagascar: Red Island Green Heart, Nat Quansah Sep 1992

Madagascar: Red Island Green Heart, Nat Quansah

Nat Quansah

No abstract provided.


Importance Of Biodiversity For Our Development (Earth Summit), Nat Quansah May 1992

Importance Of Biodiversity For Our Development (Earth Summit), Nat Quansah

Nat Quansah

No abstract provided.


Madagascar: Island Of Ghosts, Nat Quansah Sep 1991

Madagascar: Island Of Ghosts, Nat Quansah

Nat Quansah

No abstract provided.


The Search For Medicinal Plants Among Madagascar’S Tsimihety Ethnic Group, Nat Quansah Sep 1989

The Search For Medicinal Plants Among Madagascar’S Tsimihety Ethnic Group, Nat Quansah

Nat Quansah

No abstract provided.


University Of London Expedition To Madagascar Report, Nat Quansah Sep 1986

University Of London Expedition To Madagascar Report, Nat Quansah

Nat Quansah

No abstract provided.