Physical Sciences and Mathematics Commons^™

Volumetric Imaging Using The Pupil-Matched Remote Focusing Technique In Light-Sheet Microscopy, Sayed Hassan Dibaji Foroushani

Optical Science and Engineering ETDs

ABSTRACT

The dissertation explores innovative techniques in light sheet microscopy, a pivotal tool in biomedical imaging, to enhance its speed, resolution, and efficiency in capturing dynamic biological processes. Light sheet microscopy allows for quick 3D imaging of biological specimens ranging from cells to organs with high spatiotemporal resolution, large field-of-view, and minimal damage, making it vital for in vivo imaging.

The first project introduces a novel optical concept designed to optimize Axially Swept Light Sheet Microscopy (ASLM). This technique is crucial for imaging specimens ranging from live cells to chemically cleared organs due to its versatility across different immersion media. …

Radio Insights Into Gamma-Ray Mysteries, Seth M. Bruzewski

Physics & Astronomy ETDs

In the time since its launch, the \textit{Fermi Gamma-Ray Space Telescope} has provided new and unparalleled views of the $\gamma$-ray sky, dramatically increasing our understanding of sources of high-energy radiation. During that same time, however, its ``unassociated'' sources have provided a consistent mystery: approximately one third of the modern gamma-ray sky remains completely unaccounted for in other electromagnetic regimes. While some of the fainter sources simply pose challenges in achieving the necessary signal-to-noise ratio, others are well constrained and have resisted traditional investigations for years, and in some cases, for over a decade. Radio astronomy has traditionally been the best …

Modeling Lithographic Quantum Dots And Donors For Quantum Computation And Simulation, Mitchell Ian Brickson

Physics & Astronomy ETDs

Our first focus is on few-hole quantum dots in germanium. We use discontinous Galerkin methods to discretize and solve the equations of a highly detailed k·p model that describes these systems, enabling a better understanding of experimental magnetospectroscopy results. We confirm the expected anisotropy of single-hole g-factors and describe mechanisms by which different orbital states have different g-factors. Building on this, we show that the g-factors in Ge holes are suciently sensitive to details of the device electrostatics that magnetospectroscopy data can be used to make a prediction of the underlying confinement potential. The second focus is on designing quantum …

Understanding The Nature Of Pulsars And Characterizing Propagation Effects Using Pulsar Timing, Pratik Kumar

Physics & Astronomy ETDs

Pulsars are highly magnetized stellar remnants, among the densest known objects, and primarily produce radio emission in the form of lighthouse beams sweeping across the line of sight as a regular train of pulses. Apart from providing tests for matter in high-density regimes, general relativity, and plasma emission; perhaps the most notable characteristic is their applicability as precise astronomical clocks to measure various effects. Pulsar Timing Arrays (PTAs) are galactic scale detectors analogous to ground-based detectors of Gravitational Waves (GWs) like LIGO, with the aim of detecting low-frequency nano-Hz GWs from coalescing binary supermassive black holes. PTAs consist of a …

Super-Resolution Microscopy With Color Centers In Diamond, Forrest A. Hubert

Optical Science and Engineering ETDs

This dissertation explores the development and application of diamond color centers, specifically the silicon-vacancy (SiV) and nitrogen-vacancy (NV) centers, in super-resolution microscopy and magnetic imaging techniques. It demonstrates the potential of SiV centers as photostable fluorophores in stimulated emission depletion (STED) microscopy, with a resolution of approximately 90 nm. The research also presents a method for nanoscale magnetic microscopy using NV centers by combining charge state depletion (CSD) microscopy with optically detected magnetic resonance (ODMR) to image magnetic fields produced by 30 nm iron-oxide nanoparticles. The individual magnetic feature width reaches ~100 nm while resolving magnetic field patterns from nanoparticles …

Near- And Far- Field Optical Response Of Ensembles Of Nanostructures, Lauren Zundel

Physics & Astronomy ETDs

The ability of metallic nanostructures to support collective oscillations of their conduction electrons, known as surface plasmons, makes them attractive candidates for a wide range of applications in areas as diverse as cancer therapy, biosensing, and solar energy harvesting. These applications are especially promising for periodic arrays of nanostructures, which can support collective modes known as lattice resonances, and for nanostructures with extreme aspect ratios that give rise to enhanced light-matter interaction. In this Thesis, we employ a coupled dipole model to theoretically explore the lattice resonances supported by complex arrays of nanoparticles containing multiple nanoparticles per unit cell. We …

Application Of Quantum Mechanical Techniques To Optical Waveguide Structures, Stuart Ward

Physics & Astronomy ETDs

The focus of this dissertation is on the application of supersymmetric quantum mechanics to the problem of microbending in optical waveguides and on the analysis of soliton decay due solely to quantum mechanical effects.

The techniques of supersymmetric quantum mechanics are applied to the equation of motion describing light propagation in an optical waveguide which is undergoing microbending. Based on these supersymmetric techniques, given a particular refractive index profile, one may derive a new refractive index profile which results in less loss due to the microbending -- the particular example of the monomial index profile is analyzed in detail. An …

High-Power Laser Cooling And Temperature-Dependent Fluorescence Studies Of Ytterbium Doped Silica, Brian Topper

Optical Science and Engineering ETDs

Experimental observation of optical refrigeration using ytterbium doped silica glass in recent years has created a new solution for heat mitigation in high-power laser systems, nonlinear fiber experiments, integrated photonics, and precision metrology. Current efforts of different groups focus on compositional optimization, fiber fabrication, and investigating how much silica can be cooled with a laser. At the start of this work, the best effort in laser cooling ytterbium doped silica saw cooling by 6 K from room temperature. This dissertation follows the experimental efforts that culminated in the increase of this initial record by one order of magnitude. Comprehensive spectroscopic …

Modified Geometries, Clifford Algebras And Graphs: Their Impact On Discreteness, Locality And Symmetr, Roman Sverdlov

Mathematics & Statistics ETDs

In this dissertation I will explore the question whether various entities commonly used in quantum field theory can be “constructed". In particular, can spacetime be “constructed" out of building blocks, and can Berezin integral be “constructed" in terms of Riemann integrals.

As far as “constructing" spacetime out of building blocks, it has been attempted by multiple scientific communities and various models were proposed. But the common downfall is they break the principles of relativity. I will explore the ways of doing so in such a way that principles of relativity are respected. One of my approaches is to replace points …

Filaments And Their Application To Air Lasing, Spectroscopy, And Guided Discharge, Ali Rastegari

Optical Science and Engineering ETDs

Laser filamentation is a fascinating phenomenon that occurs when an intense laser beam travels through transparent materials, in particular air. At sufficiently high power (TW in the near IR, GW in the UV), instead of spreading out like a regular laser beam, something remarkable happens: the laser beam becomes tightly focused, creating a thin and intense column of light called a laser filament. Laser filamentation is characterized by two main properties: (I) a high-intensity core that remains narrow over long distances beyond the Rayleigh range and (II) a low-density plasma channel within the core. In recent years, laser filamentation has …

Rigorous Analysis Of Markov Processes With Applications To Quantum Information, Samuel Edwin Slezak

Physics & Astronomy ETDs

We present a rigorous analysis of the rapid convergence of techniques based on Markov chains for the simulation of thermal quantum systems. We show that a classical computing algorithm called path integral Monte Carlo is capable of simulating thermal states of transverse field Ising models above a threshold temperature by demonstrating the existence of a rapidly mixing Markov chain. We then turn to quantum computing algorithms and show that an idealized version of quantum Metropolis sampling can efficiently simulate systems that satisfy the eigenstate thermalization hypothesis. In a related result, we find a class of stoquastic frustration free Hamiltonians that …

The Quantum Computational Utility Of Symmetry-Protected Topological Order: From Near-Term Advantages To Universal Measurement-Based Quantum Computing, Austin Kevin Daniel

Physics & Astronomy ETDs

Quantum computers offer new avenues to approach difficult problems by taking advantage of the strange and often nonintuitive phenomena present in quantum physics. Though many quantum algorithms are believed or known to outperform the best known classical algorithms, the fundamental mechanism granting them their power remains elusive. In measurement-based quantum computation (MBQC), two key resources have been show to enable universal and provably nonclassical quantum computations, respectively. These are symmetry-protected topological order (SPTO), a notion describing a class of quantum magnets with hidden long-range correlations in their entanglement structure, and quantum contextuality, the fact that a quantum measurement outcome inherently …

Femtotesla Magnetometry And Nanoscale Imaging With Color Centers In Diamond, Yaser Silani

Optical Science and Engineering ETDs

Intriguing photophysical properties of color centers in diamond make them ideal candidates for many applications from imaging and sensing to quantum networking. In the first part of this work, we have studied the silicon vacancy (SiV) centers in diamond for nanoscale imaging applications. We showed that these centers are promising fluorophores for Stimulated Emission Depletion (STED) microscopy, owing to their photostable, near-infrared emission and favorable photophysical properties. In the second part, we built a femtotesla Radio-Frequency (RF) magnetometer based on the diamond nitrogen vacancy (NV) centers and magnetic flux concentrators. We used this sensor to remotely detect Nuclear Quadrupole Resonance …