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Physics

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2009

Articles 1 - 4 of 4

Full-Text Articles in Physical Sciences and Mathematics

Modeling Effects Of Human Single Nucleotide Polymorphisms On Protein-Protein Interactions, Shaolei Teng, Thomas Madej, Anna Panchenko, Emil Alexov Mar 2009

Modeling Effects Of Human Single Nucleotide Polymorphisms On Protein-Protein Interactions, Shaolei Teng, Thomas Madej, Anna Panchenko, Emil Alexov

Publications

A large set of three-dimensional structures of 264 protein-protein complexes with known nonsynonymous single nucleotide polymorphisms (nsSNPs) at the interface was built using homology-based methods. The nsSNPs were mapped on the proteins' structures and their effect on the binding energy was investigated with CHARMM force field and continuum electrostatic calculations. Two sets of nsSNPs were studied: disease annotated Online Mendelian Inheritance in Man (OMIM) and nonannotated (non-OMIM). It was demonstrated that OMIM nsSNPs tend to destabilize the electrostatic component of the binding energy, in contrast with the effect of non-OMIM nsSNPs. In addition, it was shown that the change of …

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Interaction Of Tollmien-Schlichting Waves In The Air With The Sea Surface, Shahrdad G. Sajjadi, Harihar Khanal Jan 2009

Interaction Of Tollmien-Schlichting Waves In The Air With The Sea Surface, Shahrdad G. Sajjadi, Harihar Khanal

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No abstract provided.

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Singular Superposition/Boundary Element Method For Reconstruction Of Multi-Dimensional Heat Flux Distributions With Application To Film Cooling Holes, Mahmood Silieti, Eduardo Divo, Alain J. Kassab Jan 2009

Singular Superposition/Boundary Element Method For Reconstruction Of Multi-Dimensional Heat Flux Distributions With Application To Film Cooling Holes, Mahmood Silieti, Eduardo Divo, Alain J. Kassab

Publications

A hybrid singularity superposition/boundary element-based inverse problem method for the reconstruction of multi-dimensional heat flux distributions is developed. Cauchy conditions are imposed at exposed surfaces that are readily reached for measurements while convective boundary conditions are unknown at surfaces that are not amenable to measurements such as the walls of the cooling holes. The purpose of the inverse analysis is to determine the heat flux distribution along cooling hole surfaces. This is accomplished in an iterative process by distributing a set of singularities (sinks) inside the physical boundaries of the cooling hole (usually along cooling hole centerline) with a given …

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Invited Article: Data Analysis Of The Floating Potential Measurement Unit Aboard The International Space Station, Aroh Barjatya, Charles M. Swenson, Donald C. Thompson, Kenneth H. Wright Jan 2009

Invited Article: Data Analysis Of The Floating Potential Measurement Unit Aboard The International Space Station, Aroh Barjatya, Charles M. Swenson, Donald C. Thompson, Kenneth H. Wright

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We present data from the Floating Potential Measurement Unit (FPMU) that is deployed on the starboard truss of the International Space Station. The FPMU is a suite of instruments capable of redundant measurements of various plasma parameters. The instrument suite consists of a floating potential probe, a wide-sweeping spherical Langmuir probe, a narrow-sweeping cylindrical Langmuir probe, and a plasma impedance probe. This paper gives a brief overview of the instrumentation and the received data quality, and then presents the algorithm used to reduce I-V curves to plasma parameters. Several hours of data are presented from August 5, 2006 and March …

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