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A Study Of The Synthesis And Reactions Of Condensed Pyriadazines, Lorraine Marie Distefano

Chemistry and Chemical Biology ETDs

A special interest in a nitramine rearrangement prompted the preparation of 1,4-diaminopyridazino [4,5-d] pyridazine and the nitration of this compound. Several reactions of the intermediates, which were synthesized en route to 1,4-diaminopyridazino [4,5-d] pyridazine, were studied. Strong evidence for the existence of keto-enol tautomerism was found in the case of 1,4-dihydroxypyridazino [4,5-d] pyridazine and its derivatives.

Some reactions of 5, 8-dichloropyrazino [2,3-d] pyridazine were studied with particular interest in the nucleophilic displacement of azides and in the nitration of 5,8-dianilinopyrazino [2,3-d] pyridazine.

The nitration of diaminophthalazine was also attempted in order to perform an acid catalyzed nitramine rearrangement from one …

Some Observations On The Chemical Behavior Of Carrier-Free Iodine-131 And Dilute Carrier Iodine0127, Manning S. Reynolds

Chemistry and Chemical Biology ETDs

Unexpected behavior by very small amounts of iodine has been noted by biochemical, medical, and ecological workers. It also has been shown that mild oxidation of carrier-free iodide-131 produced previously unknown species of iodine compounds. It was of interest to determine whether such species also result from the reduction of iodate.

While studying the formation of carrier-free iodate-131 by perchloric acid oxidation of iodide-131 at elevated temperatures, it was found that the acid is not directly responsible for the formation of iodate. Instead, the oxidation is accomplished by a volatile material (thought to be chlorine dioxide) formed only in perchloric …