Physical Sciences and Mathematics Commons^™

Feel And Touch: A Haptic Mobile Game To Assess Tactile Processing, Ivonne Monarca, Monica Tentori, Franceli L. Cibrian

Engineering Faculty Articles and Research

Haptic interfaces have great potential for assessing the tactile processing of children with Autism Spectrum Disorder (ASD), an area that has been under-explored due to the lack of tools to assess it. Until now, haptic interfaces for children have mostly been used as a teaching or therapeutic tool, so there are still open questions about how they could be used to assess tactile processing of children with ASD. This article presents the design process that led to the development of Feel and Touch, a mobile game augmented with vibrotactile stimuli to assess tactile processing. Our feasibility evaluation, with 5 children …

Let's Read: Designing A Smart Display Application To Support Codas When Learning Spoken Language, Katie Rodeghiero, Yingying Yuki Chen, Annika M. Hettmann, Franceli L. Cibrian

Engineering Faculty Articles and Research

Hearing children of Deaf adults (CODAs) face many challenges including having difficulty learning spoken languages, experiencing social judgment, and encountering greater responsibilities at home. In this paper, we present a proposal for a smart display application called Let's Read that aims to support CODAs when learning spoken language. We conducted a qualitative analysis using online community content in English to develop the first version of the prototype. Then, we conducted a heuristic evaluation to improve the proposed prototype. As future work, we plan to use this prototype to conduct participatory design sessions with Deaf adults and CODAs to evaluate the …

Pre-Earthquake Ionospheric Perturbation Identification Using Cses Data Via Transfer Learning, Pan Xiong, Cheng Long, Huiyu Zhou, Roberto Battiston, Angelo De Santis, Dimitar Ouzounov, Xuemin Zhang, Xuhui Shen

Mathematics, Physics, and Computer Science Faculty Articles and Research

During the lithospheric buildup to an earthquake, complex physical changes occur within the earthquake hypocenter. Data pertaining to the changes in the ionosphere may be obtained by satellites, and the analysis of data anomalies can help identify earthquake precursors. In this paper, we present a deep-learning model, SeqNetQuake, that uses data from the first China Seismo-Electromagnetic Satellite (CSES) to identify ionospheric perturbations prior to earthquakes. SeqNetQuake achieves the best performance [F-measure (F1) = 0.6792 and Matthews correlation coefficient (MCC) = 0.427] when directly trained on the CSES dataset with a spatial window centered on the earthquake epicenter with the Dobrovolsky …

Enhancing Microbiome Host Disease Prediction With Variational Autoencoders, Celeste Manughian-Peter

Computational and Data Sciences (MS) Theses

Advancements in genetic sequencing methods for microbiomes in recent decades have permitted the collection of taxonomic and functional profiles of microbial communities, accelerating the discovery of the functional aspects of the microbiome and generating an increased interest among clinicians in applying these techniques with patients. This advancement has coincided with software and hardware improvements in the field of machine learning and deep learning. Combined, these advancements implicate further potential for progress in disease diagnosis and treatment in humans. The ability to classify a human microbiome profile into a disease category, and additionally identify the differentiating factors within the profile between …

Automated Parsing Of Flexible Molecular Systems Using Principal Component Analysis And K-Means Clustering Techniques, Matthew J. Nwerem

Computational and Data Sciences (MS) Theses

Computational investigation of molecular structures and reactions of biological and pharmaceutical interests remains a grand scientific challenge due to the size and conformational flexibility of these systems. The work requires parsing and analyzing thousands of conformations in each molecular state for meaningful chemical information and subjecting the ensemble to costly quantum chemical calculations. The current status quo typically involves a manual process where the investigator must look at each conformation, separating each into structural families. This process is time-intensive and tedious, making this process infeasible in some cases, and limiting the ability of theoreticians to study these systems. However, the …

A Quantitative Validation Of Multi-Modal Image Fusion And Segmentation For Object Detection And Tracking, Nicholas Lahaye, Michael J. Garay, Brian D. Bue, Hesham El-Askary, Erik Linstead

Mathematics, Physics, and Computer Science Faculty Articles and Research

In previous works, we have shown the efficacy of using Deep Belief Networks, paired with clustering, to identify distinct classes of objects within remotely sensed data via cluster analysis and qualitative analysis of the output data in comparison with reference data. In this paper, we quantitatively validate the methodology against datasets currently being generated and used within the remote sensing community, as well as show the capabilities and benefits of the data fusion methodologies used. The experiments run take the output of our unsupervised fusion and segmentation methodology and map them to various labeled datasets at different levels of global …

Landscape-Based Mutational Sensitivity Cartography And Network Community Analysis Of The Sars-Cov-2 Spike Protein Structures: Quantifying Functional Effects Of The Circulating D614g Variant, Gennady M. Verkhivker, Steve Agajanian, Deniz Yasar Oztas, Grace Gupta

Mathematics, Physics, and Computer Science Faculty Articles and Research

We developed and applied a computational approach to simulate functional effects of the global circulating mutation D614G of the SARS-CoV-2 spike protein. All-atom molecular dynamics simulations are combined with deep mutational scanning and analysis of the residue interaction networks to investigate conformational landscapes and energetics of the SARS-CoV-2 spike proteins in different functional states of the D614G mutant. The results of conformational dynamics and analysis of collective motions demonstrated that the D614 site plays a key regulatory role in governing functional transitions between open and closed states. Using mutational scanning and sensitivity analysis of protein residues, we identified the stability …

Hierarchical Scheduling For Real-Time Periodic Tasks In Symmetric Multiprocessing, Tom Springer, Peiyi Zhao

Engineering Faculty Articles and Research

In this paper, we present a new hierarchical scheduling framework for periodic tasks in symmetric multiprocessor (SMP) platforms. Partitioned and global scheduling are the two main approaches used by SMP based systems where global scheduling is recommended for overall performance and partitioned scheduling is recommended for hard real-time performance. Our approach combines both the global and partitioned approaches of traditional SMP-based schedulers to provide hard real-time performance guarantees for critical tasks and improved response times for soft real-time tasks. Implemented as part of VxWorks, the results are confirmed using a real-time benchmark application, where response times were improved for soft …

Computational Analysis Of Protein Stability And Allosteric Interaction Networks In Distinct Conformational Forms Of The Sars Cov 2 Spike D614g Mutant: Reconciling Functional Mechanisms Through Allosteric Model Of Spike Regulation, Gennady M. Verkhivker, Steve Agajanian, Deniz Oztas, Grace Gupta

Mathematics, Physics, and Computer Science Faculty Articles and Research

In this study, we used an integrative computational approach to examine molecular mechanisms underlying functional effects of the D614G mutation by exploring atomistic modeling of the SARS-CoV-2 spike proteins as allosteric regulatory machines. We combined coarse-grained simulations, protein stability and dynamic fluctuation communication analysis with network-based community analysis to examine structures of the native and mutant SARS-CoV-2 spike proteins in different functional states. Through distance fluctuations communication analysis, we probed stability and allosteric communication propensities of protein residues in the native and mutant SARS-CoV-2 spike proteins, providing evidence that the D614G mutation can enhance long-range signaling of the allosteric spike …

Pitcher Effectiveness: A Step Forward For In Game Analytics And Pitcher Evaluation, Christopher Watkins, Vincent Berardi, Cyril Rakovski

Mathematics, Physics, and Computer Science Faculty Articles and Research

With the introduction of Statcast in 2015, baseball analytics have become more precise. Statcast allows every play to be accurately tracked and the data it generates is easily accessible through Baseball Savant, which opens the opportunity for improved performance statistics to be developed. In this paper we propose a new tool, Pitcher Effectiveness, that uses Statcast data to evaluate starting pitchers dynamically, based on the results of in-game outcomes after each pitch. Pitcher Effectiveness successfully predicts instances where starting pitchers give up several runs, which we believe make it a new and important tool for the in-game and post-game evaluation …

A High-Precision Machine Learning Algorithm To Classify Left And Right Outflow Tract Ventricular Tachycardia, Jianwei Zhang, Guohua Fu, Islam Abudayyeh, Magdi Yacoub, Anthony Chang, William Feaster, Louis Ehwerhemuepha, Hesham El-Askary, Xianfeng Du, Bin He, Mingjun Feng, Yibo Yu, Binhao Wang, Jing Liu, Hai Yao, Hulmin Chu, Cyril Rakovski

Mathematics, Physics, and Computer Science Faculty Articles and Research

Introduction: Multiple algorithms based on 12-lead ECG measurements have been proposed to identify the right ventricular outflow tract (RVOT) and left ventricular outflow tract (LVOT) locations from which ventricular tachycardia (VT) and frequent premature ventricular complex (PVC) originate. However, a clinical-grade machine learning algorithm that automatically analyzes characteristics of 12-lead ECGs and predicts RVOT or LVOT origins of VT and PVC is not currently available. The effective ablation sites of RVOT and LVOT, confirmed by a successful ablation procedure, provide evidence to create RVOT and LVOT labels for the machine learning model.

Methods: We randomly sampled training, validation, and testing …