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Full-Text Articles in Physical Sciences and Mathematics
Development Of Bifunctional Thiourea Catalysts For Effective Direct Amidation Reactions, Alex Guzman
Development Of Bifunctional Thiourea Catalysts For Effective Direct Amidation Reactions, Alex Guzman
Summer Research
This research synthesized and analyzed novel catalysts that can effectively form amides. An amide is a chemical group commonly found in many pharmaceuticals and biochemicals, such as proteins. In fact, about 30% of pharmaceuticals contain an amide, and the formation of amides leads to corrosive and toxic by-products which are especially problematic on the large industrial scale. Green Chemistry has proven to be a critical tool in providing innovative solutions by making the industrial production of chemicals more sustainable and safe. The pharmaceutical industry has some of the most inefficient reactions in the chemical industry mainly due to the complexity …
Progress Towards The Synthesis Of Iron-Based Hydrogenation Catalysts Using Hydroxypyridine Bidentate And Tetradentate Ligands, Sara Rockow
Summer Research
This project aimed to develop tools to increase the sustainability of the pharmaceutical industry. The pharmaceutical industry is one of the largest global markets; and one of the most wasteful. Catalysis has been identified as a key tool in sustainable chemistry. One of the most important catalytic reactions in the pharmaceutical industry is the hydrogenation of carbonyl groups, which traditionally relies on transition metal complexes. These metals are environmentally harmful; this project focuses on synthesizing iron-based hydrogenation catalysts as benign alternatives. In order to form the catalysts, organic ligands need to be attached to iron precursors. Simpler model ligands were …