Physical Sciences and Mathematics Commons^™

Part I: A Concise Asymmetric Synthesis Of Microtubule Inhibitor Tryprostatin B Part Ii: Synthesis And Biological Assessment Of Histone Deacetylase (Hdac) Inhibitors Part Iii: Acid Catalyzed Reactions Of Aromatic Ketones With Ethyl Diazoacetate, Md Mizzanoor Rahaman

Theses and Dissertations

PART I: A CONCISE ASYMMETRIC SYNTHESIS OF MICROTUBULE INHIBITOR TRYPROSTATIN B

Tryprostatin (TPS) A and B, microtubule inhibitor, are the members of a family of prenylated Trp-Pro diketopiperzine alkaloids. These two natural products were isolated in 1995 from the fermentation broth of Aspergillus fumigatus BM939 by Osada and coworkers. TPS and related diketopiperazine containing compounds such as phenylahistins, spirotryprostatins, and cyclotryprostatins are inhibitors of the mammalian cell cycle. They prevent cell cycle progression at the G2/M phase through a unique mechanism consisting of inhibiting the interaction between microtubule assisted proteins (MAP-2) and the C-terminal end of tubulin. TPS A and …