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Intermolecular-Trapping Of 1,3-Dialkyl Diaziridines With Hdda-Derived Benzynes, Ramitha Rupasinghe
Intermolecular-Trapping Of 1,3-Dialkyl Diaziridines With Hdda-Derived Benzynes, Ramitha Rupasinghe
Undergraduate Research Symposium 2018
The extent to which benzynes react with various trapping agents is an important question in synthetic chemistry due to its versatility to produce products that can be used as pharmaceuticals, dyes and other complex molecules. The hexadehydro-Diels-Alder (HDDA) reaction allows the generation of benzynes in situ which then can be efficiently trapped to synthesize complex products in one step with high yields. Reactions of HDDA - derived benzynes with trapping agents such as thioamides, alcohols, pyrroles, silyl ethers and multifunctional natural products have been studied in previous research. In this research, the reactions of HDDA-derived benzynes with diaziridines is explored …