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Full-Text Articles in Physical Sciences and Mathematics
The Development Of An Effective Water-Soluble Receptor For Pyrene Derivative Dyes, Ashley Longstreet
The Development Of An Effective Water-Soluble Receptor For Pyrene Derivative Dyes, Ashley Longstreet
Undergraduate Theses and Capstone Projects
A receptor with enhanced water solubility was synthesized from an existing receptor to be used as a pyranine fluorescence quencher in endovesiculation detection assays. The existing receptor consisted of a cyclen core with four protruding arms containing an aryl nitro group at each end. Its poor water solubility limited the accuracy and precision of the endovesiculation assay because the low concentration of receptor did not match the concentration of pyranine. To increase the water solubility, ethoxy groups were attached to the ends of each arm by first selectively reducing the nitro group to an amine with NaBHU4, H2, and a …
Synthesis Of Aspernigrin A, Erica Joerger
Synthesis Of Aspernigrin A, Erica Joerger
Undergraduate Theses and Capstone Projects
Aspernigrin A is a compound correlated with inhibiting the growth of cancer cells in the colon. A five-step synthesis was designed for aspernigrin A, projected to yield four intermediates and the final product. The intermediates were analyzed by high field 1HNMR and FT-IR spectroscopy before proceeding to the next step. A model pyridone ring system was successfully prepared from a commercially available pyrone precursor in two steps. These results provide a proof of concept that the synthetic scheme should successfully yield the natural product.