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Full-Text Articles in Physical Sciences and Mathematics
Bacterial-Mediated Photocatalytic Organic Oxidation, Peter J. Pellegrinelli
Bacterial-Mediated Photocatalytic Organic Oxidation, Peter J. Pellegrinelli
Theses and Dissertations
Bacteria, though well-known and widespread in scientific application, have plenty more opportunity to grow in the field of organic synthesis. The primary objective of this project was to apply the use of bioluminescent bacteria in an organic photoredox reaction intending to use the bacteria as a renewable source of light. This sustainable method, as opposed to high wattage bulbs, paves a green pathway for organic photocatalytic reactions. Using bioluminescent E. coli, the focus was on performing organic oxidation reactions with a recyclable photocatalyst. When using bacteria in conjunction with chemicals like nitromethane, it was an obstacle to keep the E. …
Synthesis And Biological Activity Of Novel Quorum Sensing Compounds, Joseph Nicholas Capilato
Synthesis And Biological Activity Of Novel Quorum Sensing Compounds, Joseph Nicholas Capilato
Theses and Dissertations
Bacteria communicate with chemical signals in a process known as quorum sensing. This population density-dependent process involves the bacterial production, release and detection of structurally specific small molecules and enables the bacterial pathogen to regulate its virulence on a population-wide level. Using a variety of chemical and biological techniques, I have studied various quorum sensing systems in several bacteria, including Vibrio cholera and Pseudomonas aeruginosa. A key principle of this research involves the design, synthesis and testing of novel compounds for their biological activity. These molecules are typically based off of an initial lead target, which is often identified …