Physical Sciences and Mathematics Commons^™

Chronic Muscle Weakness And Mitochondrial Dysfunction In The Absence Of Sustained Atrophy In A Preclinical Sepsis Model, Allison M. Owen, Samir P. Patel, Jeffrey D. Smith, Beverly K. Balasuriya, Stephanie F. Mori, Gregory S. Hawk, Arnold J. Stromberg, Naohide Kuriyama, Masao Kaneki, Alexander G. Rabchevsky, Timothy A. Butterfield, Karyn A. Esser, Charlotte A. Peterson, Marlene E. Starr, Hiroshi Saito

Physiology Faculty Publications

Chronic critical illness is a global clinical issue affecting millions of sepsis survivors annually. Survivors report chronic skeletal muscle weakness and development of new functional limitations that persist for years. To delineate mechanisms of sepsis-induced chronic weakness, we first surpassed a critical barrier by establishing a murine model of sepsis with ICU-like interventions that allows for the study of survivors. We show that sepsis survivors have profound weakness for at least 1 month, even after recovery of muscle mass. Abnormal mitochondrial ultrastructure, impaired respiration and electron transport chain activities, and persistent protein oxidative damage were evident in the muscle of …

Predicting Tgf-Β-Induced Epithelial-Mesenchymal Transition Using Data Assimilation, Mario J. Mendez, Matthew J. Hoffman, Elizabeth M. Cherry, Dr. Christopher Lemmon, Seth Weinberg

Biology and Medicine Through Mathematics Conference

No abstract provided.

Quantifying Differences In The Interferon Signaling Network Across Cell Types, Sivan Leviyang, Igor Griva, Nate Strawn

Biology and Medicine Through Mathematics Conference

No abstract provided.

Early Events During Hepatitis B Virus Infections, Stanca Ciupe

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Modeling Of Left Ventricular Remodeling Post-Myocardial Infarction With And Without Treatment, Mehtap Lafci

Biology and Medicine Through Mathematics Conference

No abstract provided.

Age Dependent Regulation Of Cardiac Sodium Channel Gain Of Function, Madison Nowak, David Ryan King, Steven Poelzing, Seth Weinberg

Biology and Medicine Through Mathematics Conference

No abstract provided.

Robust Estimation For Factor Loadings With Application To Postpartum Depression, Kenneth Nieser

Biology and Medicine Through Mathematics Conference

No abstract provided.

Development Of A Mathematical Model For The Role Of Inflammation In Atherosclerosis, Marcella Torres, Jing Wang, Paul J. Yannie, Shobha Ghosh, Rebecca Segal, Angela Reynolds

Biology and Medicine Through Mathematics Conference

No abstract provided.

Understanding Toxin Production During Clostridioides Difficile Infection Using High Dimensional Data, Samantha Erwin, Joshua R. Fletcher, Casey M. Theriot, Cristina Lanzas

Biology and Medicine Through Mathematics Conference

No abstract provided.

Parameter Identifiability Of A Dynamical System Model Of Breathing In A Preterm Infant, Laura Ellwein Fix, Henry Rozycki

Biology and Medicine Through Mathematics Conference

No abstract provided.

Real-Time Interactive Simulation Of Human Atrial Electrical Activity On Realistic 3d Atrial Structures Using Webgl, Abouzar Kaboudian, Yanyan Ji, Elizabeth Cherry, Flavio H. Fenton

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Modeling Of Type 1 Diabetes, Gianna Wu

HMC Senior Theses

Type 1 Diabetes (T1D) is an autoimmune disease where the pancreas produces little to no insulin, which is a hormone that regulates blood glucose levels. This happens because the immune system attacks (and kills) the beta cells of the pancreas, which are responsible for insulin production. Higher levels of glucose in the blood could have very negative, long term effects such as organ damage and blindness.

To date, T1D does not have a defined cause nor cure, and research for this disease is slow and difficult due to the invasive nature of T1D experimentation. Mathematical modeling provides an alternative approach …