Physical Sciences and Mathematics Commons^™

The Synthesis And Evaluation Of The Cardiovascular Activity Of Novel Imidazole Ring Systems, Joseph E. De Los Angeles

Chemistry & Biochemistry Theses & Dissertations

An investigation was undertaken to synthesize and evaluate the cardiovascular activity of two imidazole ring systems. Imidazoles with hypotensive activity would provide novel potential antihypertensive drugs. These novel structures may also find use as chemical probes in the study of the cardiovascular system and as prototypes for other potential cardiovascular agents.

The histamine derivative, 7,7-dipyridyl-4,5,6,7-tetrahydroimidazo-[4,5-c]pyridine (ligand l), was demonstrated to possess significant hypotensive activity in laboratory rats. A 15 mg/Kg dose of ligand 1 produces a statistically significant decrease in blood pressure when injected IP. This hypotensive effect is also associated with marked increase in heart rate. Although compound 1 …

The Effect Of Dietary Fat Level On Tumor Development And Immunity In Balb/C Mice Fed Casein Of Wheat Gluten As Protein And Challenged With Herpes Type 2-Transformed Cells, Helen Drakou

Loma Linda University Electronic Theses, Dissertations & Projects

A high percentage of fat in the diet has been implicated through epidemiological studies in several human cancers. Studies in experimental animals have produced evidence that increasing the fat in the diet decreases the animal’s ability to restrict tumor development and growth. In previous work done in this laboratory with BALB/c mice injected with herpes simplex Type 2-transformed mouse cells (H238), the effects of a diet which greatly enhanced tumor growth was compared with one which restricted tumor growth. The latter, a low (5%) fat, low protein diet, in which the protein was casein, was also found to produce a …

Quick Ceph™, A Computer Program For Cephalometric Analysis And Treatment Planning, Günther Blaseio

Loma Linda University Electronic Theses, Dissertations & Projects

The quantification of cephalometric radiographs is an integral part of orthodontic treatment planning. Numerous computer programs have been designed to digitize headfilms and to provide accurate graphic output and exact measurements. Yet these early systems were either huge, bulky and expensive or were limited in their practical use. The aim of this development was to combine modern computer and electronic equipment with advanced software engineering. The result is a universal cephalometric program written in the computer language "C" with presently seven standard and virtually limitless user definable analyses, growth forecasting, mouse-driven interactive VTO, arch length calculation, superimpositions, table of values …

Correlates Of Birth Weight And Gestation Age : Baseline Data For Health Education, Adanetch Kidanemariam

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose. The study examined the correlation of maternal occupation, urinary tract infection, smoking, and working during pregnancy with infant birth weight and gestational age in order to generate baseline data for development of a health education intervention program protocol for pregnant women In the work place.

Primary Hypotheses. (1) The four maternal risk factors: (a) occupation during lifetime, (b) reported urinary tract infection, (c) cigarette smoking, (d) working, are individually and interactively correlated with infant birth weight and gestational age. (2) The effects of the interactive associations are greater on birth weight than gestational age.

Procedure. A sample of …

Amount Of Root Shortening Related To Type Of Fixed Appliance : A Comparison Of The 0.018" And 0.022" Bracket Slot, Thomas L. Thompson

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this study was to determine if a different incidence and severity of maxillary incisor apical root resorption occurs in cases treated with the 0.018 inch versus 0.022 inch slot in standard edgewise mechanics. A consecutively treated sample of 240 patients (98 boys and 142 girls), with a mean age of 13.4 years from the orthodontic clinic at Loma Linda University were studied. 120 of the cases were treated using 0.018" bracket slot with standard edgewise mechanics and 120 were treated using 0.022" non-torqued full banded standard edgewise mechanics. 60 of the cases in each of the above …

Parasite Community Structure In Summer Flounder: Paralichthys Dentatus (Linnaeus), Of The Chesapeake Bay, Maura E. Jansen

Dissertations, Theses, and Masters Projects

No abstract provided.