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Articles 1 - 5 of 5
Full-Text Articles in Physical Sciences and Mathematics
Speech Processing Approach For Diagnosing Dementia In An Early Stage, Roozbeh Sadeghian, J. David Schaffer, Stephen A. Zahorian
Speech Processing Approach For Diagnosing Dementia In An Early Stage, Roozbeh Sadeghian, J. David Schaffer, Stephen A. Zahorian
Faculty Works
The clinical diagnosis of Alzheimer’s disease and other dementias is very challenging, especially in the early stages. Our hypothesis is that any disease that affects particular brain regions involved in speech production and processing will also leave detectable finger prints in the speech. Computerized analysis of speech signals and computational linguistics have progressed to the point where an automatic speech analysis system is a promising approach for a low-cost non-invasive diagnostic tool for early detection of Alzheimer’s disease.
We present empirical evidence that strong discrimination between subjects with a diagnosis of probable Alzheimer’s versus matched normal controls can be achieved …
Towards An Automated Screening Tool For Pediatric Speech Delay, Roozbeh Sadeghian, Stephen A. Zahorian
Towards An Automated Screening Tool For Pediatric Speech Delay, Roozbeh Sadeghian, Stephen A. Zahorian
Faculty Works
Speech delay is a childhood language problem that sometimes is resolved on its own but sometimes may cause more serious language difficulties later. This leads therapists to screen children for detection at early ages in order to eliminate future problems. Using the Goldman-Fristoe Test of Articulation (GFTA) method, therapists listen to a child's pronunciation of certain phonemes and phoneme pairs in specified words and judge the child's stage of speech development. The goal of this paper is to develop an Automatic Speech Recognition (ASR) tool and related speech processing methods which emulate the knowledge of speech therapists. In this paper …
Quantifying Measurement Error In Digital Instruments, William B. Laing Iii, Sean Bryant
Quantifying Measurement Error In Digital Instruments, William B. Laing Iii, Sean Bryant
Faculty Works
A first lab experiment clearly illustrates that a glucose meter is actually an excellent source of both random and systematic error, much to the surprise to students and physicians alike. A histogram is constructed and the utility of the standard deviation and standard error to quantify the uncertainty in each measurement and in the mean value, respectively, is demonstrated. From the first lab on, students are challenged to express and interpret confidence intervals in order to form quantitative conclusions. Assessments reveal that many students find this to be surprisingly challenging.
The Physics Of Human Performance: An Ideal Lab, William B. Laing Iii, Harold Mayer
The Physics Of Human Performance: An Ideal Lab, William B. Laing Iii, Harold Mayer
Faculty Works
Physics lab goes to the gymnasium, where students calculate the mechanical power required to walk on an inclined treadmill in watts and convert to units power used to measure human performance: VO2, and METs. Students learn how to use two linear regression models: the ACSM "walking equation" to estimate the actual power expenditure of walking and the Rockport 1 mile test to estimate their own VO2max. Students use models to prescribe exercise parameters for themselves and for two cases. The IDEAL lab collaboration is developing labs that are open, applied to life, and rigorously quantitative.
Inhibition Of The Thioesterase Activity Of Human Fatty Acid Synthase By 1,4- And 9,10-Diones, Herman H. Odens
Inhibition Of The Thioesterase Activity Of Human Fatty Acid Synthase By 1,4- And 9,10-Diones, Herman H. Odens
Faculty Works
Fatty acid synthase (FASN) is the enzyme that synthesizes fatty acids de novo in human cells. Although FASN is generally expressed at low levels in most normal tissues, its expression is highly upregulated in many cancers. Consistent with this notion, inhibition of FASN activity has demonstrated potential to halt proliferation and induce cell death in vitro and to block tumor growth in vivo. Consequently, FASN is widely recognized as a valuable therapeutic target. In this report, we describe a variety of 1,4-quinones and 9,10- anthraquinones, including several natural compounds and some newly synthesized compounds, that potently inhibit the thioesterase (TE) …