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Full-Text Articles in Physical Sciences and Mathematics
Image-Guided Proton Therapy For Online Dose-Evaluation And Adaptive Planning, Joey P. Cheung
Image-Guided Proton Therapy For Online Dose-Evaluation And Adaptive Planning, Joey P. Cheung
Dissertations & Theses (Open Access)
The main advantage for using protons in radiotherapy is their finite range in patients, allowing for potential improved sparing of normal tissues. However, this comes at a cost of increased sensitivity to range uncertainties. Density changes along the beam path will affect the proton range and the resultant dose distribution, making it difficult to estimate the impact of visible anatomic changes to the patient dose distribution. In order to better understand the effect of anatomy change on proton dose, some form of treatment-time verification is required and methods to correct for observed changes would be beneficial. Therefore, this project aims …
Benchmarking And Implementation Of A New Independent Monte Carlo Dose Calculation Quality Assurance Audit Tool For Clinical Trials, Scott E. Davidson
Benchmarking And Implementation Of A New Independent Monte Carlo Dose Calculation Quality Assurance Audit Tool For Clinical Trials, Scott E. Davidson
Dissertations & Theses (Open Access)
Introduction Commercial treatment planning systems employ a variety of dose calculation algorithms to plan and predict the dose distributions a patient receives during external beam radiation therapy. Traditionally, the Radiological Physics Center has relied on measurements to assure that institutions participating in the National Cancer Institute sponsored clinical trials administer radiation in doses that are clinically comparable to those of other participating institutions. To complement the effort of the RPC, an independent dose calculation tool needs to be developed that will enable a generic method to determine patient dose distributions in three dimensions and to perform retrospective analysis of radiation …
Thoracic Radiotherapy Treatment Planning With Cine Pet/Ct, Adam C. Riegel
Thoracic Radiotherapy Treatment Planning With Cine Pet/Ct, Adam C. Riegel
Dissertations & Theses (Open Access)
Purpose: Respiratory motion causes substantial uncertainty in radiotherapy treatment planning. Four-dimensional computed tomography (4D-CT) is a useful tool to image tumor motion during normal respiration. Treatment margins can be reduced by targeting the motion path of the tumor. The expense and complexity of 4D-CT, however, may be cost-prohibitive at some facilities. We developed an image processing technique to produce images from cine CT that contain significant motion information without 4D-CT. The purpose of this work was to compare cine CT and 4D-CT for the purposes of target delineation and dose calculation, and to explore the role of PET in target …