Physical Sciences and Mathematics Commons^™

Linkage Disequilibrium In Wild Mice, Cathy C. Laurie, Deborah A. Nickerson, Amy D. Anderson, Bruce S. Weir, Robert J. Livingston, Matthew D. Dean, Kimberly L. Smith, Eric E. Schadt, Michael W. Nachman

Mathematics Faculty Publications

Crosses between laboratory strains of mice provide a powerful way of detecting quantitative trait loci for complex traits related to human disease. Hundreds of these loci have been detected, but only a small number of the underlying causative genes have been identified. The main difficulty is the extensive linkage disequilibrium (LD) in intercross progeny and the slow process of fine-scale mapping by traditional methods. Recently, new approaches have been introduced, such as association studies with inbred lines and multigenerational crosses. These approaches are very useful for interval reduction, but generally do not provide single-gene resolution because of strong LD extending …