Physical Sciences and Mathematics Commons^™

Regulation Of Mirnas In Obesity And Diabetes, Eva Maher, Ava O'Meara, Cathy Brougham

SURE Journal: Science Undergraduate Research Experience Journal

Introduction: The prevalence of obesity and obesity-related secondary disorders has increased dramatically in recent years. Dysregulated microRNA (miRNA) expression has been linked to the development of obesity and its associated disorders. Adipose derived stem cells (ADSCs) are promising cell models of obesity, obesity-related inflammation and diabetes. Furthermore, miRNA expression profiles have emerged as promising targets for the novel treatment of diseases such as obesity. In order to enhance miRNA-based therapies, the miRNA expression profile of obesity and its related disorders must be monitored to further understand the underlying mechanisms of obesity and to identify novel targets.

Aim: The aim of …

The Potential Of Stem Cell Therapy In Multiple Sclerosis Treatment: A Review, Sorina Amarculesei, Ava O'Meara Cushen, Cathy Brougham

SURE Journal: Science Undergraduate Research Experience Journal

Multiple Sclerosis is an autoimmune and neurodegenerative disease of the central nervous system. There are currently 2.8 million people living with Multiple Sclerosis worldwide, including 9000 people in Ireland, with a prevalence of 193 per 100,000 people. Symptoms of Multiple Sclerosis include sensory loss, fatigue, cognitive dysfunction, spasticity, depression, optic neuritis, gait ataxia, diplopia, and loss of bladder control. Currently, there is no standardised treatment or cure for Multiple Sclerosis with many strategies focusing on symptoms. Stem cells have emerged as promising approaches for Multiple Sclerosis therapeutics. Clinical trials primarily focus on mesenchymal stem cell-based therapies for Multiple Sclerosis. Furthermore, …

Editorial - Sure Journal Vol 5, Anne M. Friel

SURE Journal: Science Undergraduate Research Experience Journal

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The Acute Effects Of Talocrural Mwm Compared With The Application Of Soft-Tissue Of The Plantarfascia On Chronic Lateral Ankle Sprains For Ankle Dorsiflexion R.O.M., Peter Hempenstall, Brian O'Rourke

SURE Journal: Science Undergraduate Research Experience Journal

Previous research has looked at various treatment remedies for improving acute ankle Dorsiflexion Range of Motion (DFROM) post chronic Lateral Ankle Sprain (LAS). Mulligan’s Mobilisation with Movement (MWM) appears frequently however, the significance and mechanism remain quite conflicting (Gilbreath et al., 2015). It is also known that after a LAS, the Lateral Ligament Complex (LLC) is compromised and the calcaneus inverts, increasing stiffness of plantarfascia (Al-Mohrej & Al-Kenani, 2016, Denegar et al., 2002, Loudon & Bell, 1996). The objective of this study was to further explore the effectiveness of MWM compared with soft-tissue (ST) application of the plantarfascia on acute …

Therapies For Mitochondrial Disorders, Kayli Sousa Smyth, Anne Mulvihill

SURE Journal: Science Undergraduate Research Experience Journal

Mitochondria are cytoplasmic, double-membrane organelles that synthesise adenosine triphosphate (ATP). Mitochondria contain their own genome, mitochondrial DNA (mtDNA), which is maternally inherited from the oocyte. Mitochondrial proteins are encoded by either nuclear DNA (nDNA) or mtDNA, and both code for proteins forming the mitochondrial oxidative phosphorylation (OXPHOS) complexes of the respiratory chain. These complexes form a chain that allows the passage of electrons down the electron transport chain (ETC) through a proton motive force, creating ATP from adenosine diphosphate (ADP). This study aims to explore current and prospective therapies for mitochondrial disorders (MTDS). MTDS are clinical syndromes coupled with abnormalities …

Emerging Technologies: Empowering People To Capture, Share And Transfer Tacit Knowledge, Donncadh J. Nagle, Melanie J. Adams

Level 3

ICH Q10 was published in 2008, and presented a model for an effective Pharmaceutical Quality System (PQS). However, the industry still has some way to go in embracing and implementing its principles in order to achieve greater product realisation, to establish and maintain a state of control, and to facilitate continual improvement.

ICH Q10 introduced us to two key enablers: Knowledge Management (KM) and Quality Risk Management (QRM).^[1] While the pharmaceutical industry has made progress in implementing the principles of QRM since 2008, there has been significantly slower progress in implementing knowledge management practices. However, there may be solutions …

Steps Towards Digital Transformation In The Pharmaceutical Manufacturing Landscape Knowledge-Enabled Technology Transfer, Anne Greene Professor, Martin Lipa Dr

Level 3

No abstract provided.

Managing Risk And Knowledge: Frameworks To Guide Knowledge-Enabled Technology Transfer, Martin Lipa Dr, Anne Greene

Level 3

Technology transfer is not only about the transfer of technology, but also about the transfer of knowledge, as evidenced by definitions of KM within the biopharma industry and beyond. However, knowledge transfer is often not well structured and its effectiveness – in particular for tacit knowledge (i.e., know how) – is an opportunity for improvement which can lead to many benefits. This article profiles recent research into the topic of improving knowledge transfer during technology transfer and presents several recently developed frameworks for improving such. The article furthermore explains how the frameworks can be co-deployed in support of robust knowledge …

Application Of Competitive Intelligence For Insular Territories: Automatic Analysis Of Scientific And Technology Trends To Fight The Negative Effects Of Climate Change, Henri Dou, Pierre Fournie

International Journal of Islands Research

Islands are fragile territories because of their geographical position. As a result, climate impacts can have serious consequences, of which some are irreversible. Therefore, it is necessary to allow insular territories to benefit from the latest scientific and technological advances in combating climate effects. The current article shows how to deal with automatic analysis of scientific information on the one hand, but also its applications via patents. We will analyse the latest scientific results as well as their possible applications using patent analysis. We will also focus on experts, laboratories, and leading companies, that are active on the field. The …