Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Aged (1)
- Alzheimer Disease (1)
- Alzheimer's disease (1)
- Animals (1)
- Apolipoprotein E (1)
-
- Apolipoprotein E4 (1)
- Bioreactors (1)
- Brain (1)
- Cardiovascular (1)
- Cattle (1)
- Cell Membrane (1)
- Cells (1)
- Cells, Cultured (1)
- Computational Biology (1)
- Computer Simulation (1)
- Cultured (1)
- Dementia (1)
- Diffusion Tensor Imaging (1)
- Diffusion tensor (1)
- Early Diagnosis (1)
- Endothelial Cells (1)
- Epidermal Growth Factor (1)
- Female (1)
- Fibroblast Growth Factor (1)
- Fibroblast Growth Factor 2 (1)
- Fractional anisotropy (1)
- Heparan Sulfate Proteoglycans (1)
- Heparin Lyase (1)
- Humans (1)
- Image Processing, Computer-Assisted (1)
Articles 1 - 2 of 2
Full-Text Articles in Physical Sciences and Mathematics
Endothelial Cell Capture Of Heparin-Binding Growth Factors Under Flow, Bing Zhao, Changjiang Zhang, Kimberly Forsten-Williams, Jun Zhang, Michael Fannon
Endothelial Cell Capture Of Heparin-Binding Growth Factors Under Flow, Bing Zhao, Changjiang Zhang, Kimberly Forsten-Williams, Jun Zhang, Michael Fannon
Ophthalmology and Visual Science Faculty Publications
Circulation is an important delivery method for both natural and synthetic molecules, but microenvironment interactions, regulated by endothelial cells and critical to the molecule's fate, are difficult to interpret using traditional approaches. In this work, we analyzed and predicted growth factor capture under flow using computer modeling and a three-dimensional experimental approach that includes pertinent circulation characteristics such as pulsatile flow, competing binding interactions, and limited bioavailability. An understanding of the controlling features of this process was desired. The experimental module consisted of a bioreactor with synthetic endothelial-lined hollow fibers under flow. The physical design of the system was incorporated …
White Matter Diffusion Alterations In Normal Women At Risk Of Alzheimer's Disease, Charles D. Smith, Himachandra Chebrolu, Anders H. Andersen, David A. Powell, Mark A. Lovell, Shuling Xiong, Brian T. Gold
White Matter Diffusion Alterations In Normal Women At Risk Of Alzheimer's Disease, Charles D. Smith, Himachandra Chebrolu, Anders H. Andersen, David A. Powell, Mark A. Lovell, Shuling Xiong, Brian T. Gold
Neurology Faculty Publications
Increased white matter mean diffusivity and decreased fractional anisotropy (FA) has been observed in subjects diagnosed with mild cognitive impairment (MCI) and Alzheimer's disease (AD). We sought to determine whether similar alterations of white matter occur in normal individuals at risk of AD. Diffusion tensor images were acquired in 42 cognitively normal right-handed women with both a family history of dementia and at least one apolipoprotein E4 allele. These were compared with images from 23 normal women without either AD risk factor. Group analyses were performed using tract-based spatial statistics. Reduced FA was observed in the fronto-occipital and inferior temporal …