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Articles 1 - 7 of 7
Full-Text Articles in Physical Sciences and Mathematics
Abstract 4525: Hypoxia Signaling Pathway Plays A Role In Ovarian Cancer Chemoresistance, Noelle L. Cutter Ph.D., Tyler Walther Bsc, Kim Doyle, Ryan Frank
Abstract 4525: Hypoxia Signaling Pathway Plays A Role In Ovarian Cancer Chemoresistance, Noelle L. Cutter Ph.D., Tyler Walther Bsc, Kim Doyle, Ryan Frank
Faculty Works: Biology, Chemistry, and Environmental Studies
Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor that when induced regulates the expression of many genes involved in cytoprotective stimuli, which attenuates apoptosis and improves survival. Increased expression of HIF-1α gene (HIF1A) has been found in several carcinomas, including ovarian cancer. Ovarian cancers are generally refractory to platinum-based chemotherapy. Despite the large number of studies, molecular events that govern the emergence of aggressive therapy-resistant cells after chemotherapy are poorly defined. Genomic instabilities, such as copy number variation(CNV), may play an important role in chemoresistance and have been implicated in many complex diseases, like cancer.. We analyzed CNV …
Novel Role Of Hypoxia In Ovarian Cancer Chemo Resistance Through Epigenetic Regulation Of Hif1Α, Noelle L. Cutter Ph.D., Tyler Walther Bsc, Liam Gallagher, Michael O'Sullivan, Benjamin Honigsfeld, Kim Doyle, Nevenka Dimitrova, Robert Lucito
Novel Role Of Hypoxia In Ovarian Cancer Chemo Resistance Through Epigenetic Regulation Of Hif1Α, Noelle L. Cutter Ph.D., Tyler Walther Bsc, Liam Gallagher, Michael O'Sullivan, Benjamin Honigsfeld, Kim Doyle, Nevenka Dimitrova, Robert Lucito
Faculty Works: Biology, Chemistry, and Environmental Studies
Ovarian cancer is the fifth deadliest cancer in woman, and epithelial malignancies account for 90% of cases. Tumor recurrence after chemotherapy or radiation remains a major obstacle to successful ovarian cancer treatment. Despite the large number of studies, molecular events that govern the emergence of aggressive therapy-resistant cells after chemotherapy are poorly defined. Genetic modifications, such as copy number variation (CNV), play an important role in controlling the expression of genes that are involved in chemo resistance. We analyzed CNV data that is publically available through the Cancer Genome Atlas and others. Of particular interest was the transcription factor HIF1α …
Abstract 2934: Gsk3Β Modulates Chemoresistance In Epithelial Ovarian Cancer, Noelle L. Cutter Ph.D., Naeha Pathak
Abstract 2934: Gsk3Β Modulates Chemoresistance In Epithelial Ovarian Cancer, Noelle L. Cutter Ph.D., Naeha Pathak
Faculty Works: Biology, Chemistry, and Environmental Studies
Introduction: Epithelial ovarian cancer is one of the most common gynecological malignancies and the fifth most frequent cause of cancer death in women, affecting over 22,000 women annually. Nearly 15,500 affected women die from this disease annually, and chemoresistance from the commonly prescribed platinum-based drug, carboplatin, is a major contributor to this mortality. Previous studies have identified genes with CpG islands that are methylated and transcriptionally silenced in resistant epithelial ovarian cancer patients. One of these genes is GSK3β, an important regulator of apoptosis and cell growth in the Wnt pathway. Thus, understanding the role of GSK3β suppression in chemoresistance …
Inhibitions Of Gsk3Β Modulates Cell Death In Epithelial Ovarian Cancer, Noelle L. Cutter Ph.D., Tyler Walther Bsc, Naeha Pathak
Inhibitions Of Gsk3Β Modulates Cell Death In Epithelial Ovarian Cancer, Noelle L. Cutter Ph.D., Tyler Walther Bsc, Naeha Pathak
Faculty Works: Biology, Chemistry, and Environmental Studies
Epithelial ovarian cancer is one of the most common gynecological malignancies and the fifth most frequent cause of cancer death in women, affecting over 22,000 women annually. Nearly 15,500 affected women die from this disease annually, and chemoresistance from the commonly prescribed platinum-based drug, carboplatin, is a major contributor to this mortality rate. Previous studies have identified genes with CpG islands that are methylated and transcriptionally silenced in resistant epithelial ovarian cancer patients. One of these genes is GSK3β, an important regulator of apoptosis and cell growth in the Wnt pathway. Thus, understanding the role of GSK3β suppression in chemoresistance …
Abstract 2988: Dok2 Suppression By Methylation Induces Platinum Resistance Via Suppression Of Apoptosis In Ovarian Cancer Cells., Noelle L. Cutter Ph.D., Elena Lum, Michelle Vigliotti, Nilanjana Banerjee, Sitharthan Kamalakaran, Kazimierz O. Wrzeszczynski, Sohail Khan, Nevenka Dimitrova, Douglas A. Levine, Robert Lucito
Abstract 2988: Dok2 Suppression By Methylation Induces Platinum Resistance Via Suppression Of Apoptosis In Ovarian Cancer Cells., Noelle L. Cutter Ph.D., Elena Lum, Michelle Vigliotti, Nilanjana Banerjee, Sitharthan Kamalakaran, Kazimierz O. Wrzeszczynski, Sohail Khan, Nevenka Dimitrova, Douglas A. Levine, Robert Lucito
Faculty Works: Biology, Chemistry, and Environmental Studies
Ovarian cancers are highly heterogeneous and while chemotherapy is the preferred treatment, many patients are intrinsically resistant or quickly develop resistance. Furthermore, all tumors that recur will become resistant. Recent evidence suggests that epigenetic deregulation may be a key factor in the onset and maintenance of chemoresistance. To examine the ovarian epigenome, we first analyzed a set of 43 primary ovarian tumors and 9 normal ovarian samples. Since therapy response is a significant issue for ovarian cancer patients we analyzed the epigenetic differences that segregate with platinum response. We then associated expression data to identify genes with expression changes potentially …
Abstract 3144: A Role For Dok2 Methylation In Platinum Resistance And Tumor Suppression In Ovarian Cancer, Noelle L. Cutter Ph.D., Elena Lum, Michelle Vigliotti, Sohail Khan, Douglas Levine, Nevenka Dimitrova, Robert Lucito
Abstract 3144: A Role For Dok2 Methylation In Platinum Resistance And Tumor Suppression In Ovarian Cancer, Noelle L. Cutter Ph.D., Elena Lum, Michelle Vigliotti, Sohail Khan, Douglas Levine, Nevenka Dimitrova, Robert Lucito
Faculty Works: Biology, Chemistry, and Environmental Studies
Ovarian cancer is the 5th leading cause of cancer in women, affecting close to 22,000 women in the year 2011, of which nearly 15,500 will die. It is difficult to detect until it reaches advanced stages and becomes malignant. Currently, the standard treatment for ovarian cancer is platinum-based therapeutics, such as Carboplatin or Cisplatin, combined with Taxol. Unfortunately, approximately 25% of patients are inherently platinum-resistant and all patients who suffer from recurrence will have developed acquired platinum resistance. The genetic/epigenetic causes of this resistance are poorly understood. Epigenetic events are reversible and the identification of genes altered by this mechanism …
Abstract 70: A Role For The Chromatin Remodeling Protein Chd3 In Ovarian Cancer Therapy Response, Noelle L. Cutter Ph.D., Nila Banerjee, Michelle Vigliotti, Angel Janevski, Douglas Levine, Robert Lucito, Nevenka Dimitrova
Abstract 70: A Role For The Chromatin Remodeling Protein Chd3 In Ovarian Cancer Therapy Response, Noelle L. Cutter Ph.D., Nila Banerjee, Michelle Vigliotti, Angel Janevski, Douglas Levine, Robert Lucito, Nevenka Dimitrova
Faculty Works: Biology, Chemistry, and Environmental Studies
Carboplatin and cisplatin are chemotherapeutic agents that are used extensively for treating epithelial ovarian cancer. These drugs can be highly effective, yet tumors are frequently refractory to treatment or become resistant upon tumor relapse. Epigenetic silencing, particularly at promoter regions of genes regulates important cell function and has been associated with all stages of tumor formation and progression and may contribute to therapy response. We analyzed the epigenome of 50 primary ovarian tumors and 12 normal ovarian samples using an array based method previously developed in our lab and associated Affymetrix U133 expression data. We then identified gene candidates that …