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Articles 1 - 8 of 8
Full-Text Articles in Physical Sciences and Mathematics
Optimization And Control Of Agent-Based Models In Biology: A Perspective, G. An, B. G. Fitzpatrick, S. Christley, P. Federico, A. Kanarek, R. Miller Neilan, M. Oremland, R. Salinas, R. Laubeanbacher, S. Lenhart
Optimization And Control Of Agent-Based Models In Biology: A Perspective, G. An, B. G. Fitzpatrick, S. Christley, P. Federico, A. Kanarek, R. Miller Neilan, M. Oremland, R. Salinas, R. Laubeanbacher, S. Lenhart
Ben G. Fitzpatrick
Agent-based models (ABMs) have become an increasingly important mode of inquiry for the life sciences. They are particularly valuable for systems that are not understood well enough to build an equation-based model. These advantages, however, are counterbalanced by the difficulty of analyzing and using ABMs, due to the lack of the type of mathematical tools available for more traditional models, which leaves simulation as the primary approach. As models become large, simulation becomes challenging. This paper proposes a novel approach to two mathematical aspects of ABMs, optimization and control, and it presents a few first steps outlining how one might …
Development And Implementation Of An Optimization Model To Improve Airport Security., Kassandra Guajardo, Angela Waterworth, Robert Brigantic Ph.D.
Development And Implementation Of An Optimization Model To Improve Airport Security., Kassandra Guajardo, Angela Waterworth, Robert Brigantic Ph.D.
STAR Program Research Presentations
What if airport security teams across the world could quantify and then minimize the amount of risk throughout areas of an airport? The Operations Research Team at the Pacific Northwest National Laboratory is developing and implementing an optimization model called ARAM (Airport Risk Analysis Model) for the Seattle-Tacoma International Airport. ARAM will provide a recommended optimal deployment of security assets to reduce risk in areas of an airport. The model is based on a risk equation that considers consequences, vulnerabilities, and threat magnitudes at airports. ARAM will also provide the estimated risk buy down percentage, which is how much risk …
Deterministic And Probabilistic Methods For Seismic Source Inversion, Juan Pablo Madrigal Cianci
Deterministic And Probabilistic Methods For Seismic Source Inversion, Juan Pablo Madrigal Cianci
Mathematics & Statistics ETDs
The national Earthquake Information Center (NEIC) reports an occurrence of about 13,000 earthquakes every year, spanning different values on the Richter scale from very mild (2) to "giant earthquakes'' (8 and above). Being able to study these earthquakes provides useful information for a wide range of applications in geophysics. In the present work we study the characteristics of an earthquake by performing seismic source inversion; a mathematical problem that, given some recorded data, produces a set of parameters that when used as input in a mathematical model for the earthquake generates synthetic data that closely resembles the measured data. There …
An Adaptive Total Variation Algorithm For Computing The Balanced Cut Of A Graph, Xavier Bresson, Thomas Laurent, David Uminsky, James H. Von Brecht
An Adaptive Total Variation Algorithm For Computing The Balanced Cut Of A Graph, Xavier Bresson, Thomas Laurent, David Uminsky, James H. Von Brecht
Thomas Laurent
We propose an adaptive version of the total variation algorithm proposed in [3] for computing the balanced cut of a graph. The algorithm from [3] used a sequence of inner total variation minimizations to guarantee descent of the balanced cut energy as well as convergence of the algorithm. In practice the total variation minimization step is never solved exactly. Instead, an accuracy parameter is specified and the total variation minimization terminates once this level of accuracy is reached. The choice of this parameter can vastly impact both the computational time of the overall algorithm as well as the accuracy of …
Convergence Of A Steepest Descent Algorithm For Ratio Cut Clustering, Xavier Bresson, Thomas Laurent, David Uminsky, James H. Von Brecht
Convergence Of A Steepest Descent Algorithm For Ratio Cut Clustering, Xavier Bresson, Thomas Laurent, David Uminsky, James H. Von Brecht
Thomas Laurent
Unsupervised clustering of scattered, noisy and high-dimensional data points is an important and difficult problem. Tight continuous relaxations of balanced cut problems have recently been shown to provide excellent clustering results. In this paper, we present an explicit-implicit gradient flow scheme for the relaxed ratio cut problem, and prove that the algorithm converges to a critical point of the energy. We also show the efficiency of the proposed algorithm on the two moons dataset.
Optimization Of A Fuel Cell, Eduardo Gines
Optimization Of A Fuel Cell, Eduardo Gines
Undergraduate Journal of Mathematical Modeling: One + Two
Fuel cells are devices that generate energy from a chemical reaction that takes place inside the cell. The main parts of these devices are two electrodes and an electrolyte solution. The project consists of determining the area of the electrodes for the fuel cell at which the cell produces its maximum amount of power. This was done with the performance curve of the fuel cell which was in terms of voltage vs current density. The performance curve was turned into terms of power density vs current density, and through this curve the maximum power was determined by identifying the maximum …
Optimization And Control Of Agent-Based Models In Biology: A Perspective, G. An, B. G. Fitzpatrick, S. Christley, P. Federico, A. Kanarek, R. Miller Neilan, M. Oremland, R. Salinas, R. Laubeanbacher, S. Lenhart
Optimization And Control Of Agent-Based Models In Biology: A Perspective, G. An, B. G. Fitzpatrick, S. Christley, P. Federico, A. Kanarek, R. Miller Neilan, M. Oremland, R. Salinas, R. Laubeanbacher, S. Lenhart
Mathematics Faculty Works
Agent-based models (ABMs) have become an increasingly important mode of inquiry for the life sciences. They are particularly valuable for systems that are not understood well enough to build an equation-based model. These advantages, however, are counterbalanced by the difficulty of analyzing and using ABMs, due to the lack of the type of mathematical tools available for more traditional models, which leaves simulation as the primary approach. As models become large, simulation becomes challenging. This paper proposes a novel approach to two mathematical aspects of ABMs, optimization and control, and it presents a few first steps outlining how one might …
Network Analytics For The Mirna Regulome And Mirna-Disease Interactions, Joseph Jayakar Nalluri
Network Analytics For The Mirna Regulome And Mirna-Disease Interactions, Joseph Jayakar Nalluri
Theses and Dissertations
miRNAs are non-coding RNAs of approx. 22 nucleotides in length that inhibit gene expression at the post-transcriptional level. By virtue of this gene regulation mechanism, miRNAs play a critical role in several biological processes and patho-physiological conditions, including cancers. miRNA behavior is a result of a multi-level complex interaction network involving miRNA-mRNA, TF-miRNA-gene, and miRNA-chemical interactions; hence the precise patterns through which a miRNA regulates a certain disease(s) are still elusive. Herein, I have developed an integrative genomics methods/pipeline to (i) build a miRNA regulomics and data analytics repository, (ii) create/model these interactions into networks and use optimization techniques, motif …