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Physical Sciences and Mathematics Commons™
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Full-Text Articles in Physical Sciences and Mathematics
Identification Of Biologically Essential Nodes Via Determinative Power In Logical Models Of Cellular Processes, Trevor Pentzien, Bhanwar L. Puniya, Tomáš Helikar, Mihaela Teodora Matache
Identification Of Biologically Essential Nodes Via Determinative Power In Logical Models Of Cellular Processes, Trevor Pentzien, Bhanwar L. Puniya, Tomáš Helikar, Mihaela Teodora Matache
Mathematics Faculty Publications
A variety of biological networks can bemodeled as logical or Boolean networks. However, a simplification of the reality to binary states of the nodes does not ease the difficulty of analyzing the dynamics of large, complex networks, such as signal transduction networks, due to the exponential dependence of the state space on the number of nodes. This paper considers a recently introduced method for finding a fairly small subnetwork, representing a collection of nodes that determine the states of most other nodes with a reasonable level of entropy. The subnetwork contains the most determinative nodes that yield the highest information …
Yeast Through The Ages: A Statistical Analysis Of Genetic Changes In Aging Yeast, Alison Wise '05, Johanna S. Hardin, Laura Hoopes
Yeast Through The Ages: A Statistical Analysis Of Genetic Changes In Aging Yeast, Alison Wise '05, Johanna S. Hardin, Laura Hoopes
Pomona Faculty Publications and Research
Microarray technology allows for the expression levels of thousands of genes in a cell to be measured simultaneously. The technology provides great potential in the fields of biology and medicine, as the analysis of data obtained from microarray experiments gives insight into the roles of specific genes and the associated changes across experimental conditions (e.g., aging, mutation, radiation therapy, drug dosage). The application of statistical tools to microarray data can help make sense of the experiment and thereby advance genetic, biological, and medical research. Likewise, microarrays provide an exciting means through which to explore statistical techniques.