Physical Sciences and Mathematics Commons^™

Modeling The Effects Of Transforming Growth Factor-Beta On Extracellular Matrix Alignment In Dermal Wound Repair, J. C. Dallon, J. A. Sherratt, P. K. Maini

Faculty Publications

We present a novel mathematical model for collagen deposition and alignment during dermal wound healing, focusing on the regulatory effects of TGF. Our work extends a previously developed model which considers the interactions between fibroblasts and extracellular matrix, composed of collagen and a fibrin based blood clot, by allowing fibroblasts to orient the collagen matrix, and produce and degrade the extracellular matrix, while the matrix can direct the fibroblasts and control their speed. Here we extend the model by allowing a time varying concentration of TGF to alter the properties of the fibroblasts. Thus we are able to simulate experiments …