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Full-Text Articles in Physical Sciences and Mathematics
Synthesis Of Thiol-Acrylate Hydrogels For 3d Cell Culture And Microfluidic Applications, Anowar Hossain Khan
Synthesis Of Thiol-Acrylate Hydrogels For 3d Cell Culture And Microfluidic Applications, Anowar Hossain Khan
LSU Doctoral Dissertations
Globally cell culture is an $18.98 billion industry as of 2020, with an 11.6 percent annual growth rate. Drug discovery has an estimated worth of $69.8 billion in 2020 and is predicted to grow to $110.4 billion by 2025. Three-dimensional (3D) cell culture of cancer cells is one of the rapidly growing felids since it better recapitulates in vivo conditions compared to two-dimensional (2D) models. However, it is challenging to grow 3D tumor spheroids outside the body, and some of the existing technology can generate these spheroids outside the human body but poorly mimic in vivo tumor models. Therefore, there …
Fabrication And Characterization Of Autonomously Self-Healable And Stretchable Soft Microfluidics, Hualong Wang, Susanna Vu, Julia Pignanelli, Tamer Abdel Fatah, John F. Trant, Sara Mahshid, Simon Rondeau-Gagné, Mohammed Jalal Ahamed
Fabrication And Characterization Of Autonomously Self-Healable And Stretchable Soft Microfluidics, Hualong Wang, Susanna Vu, Julia Pignanelli, Tamer Abdel Fatah, John F. Trant, Sara Mahshid, Simon Rondeau-Gagné, Mohammed Jalal Ahamed
Chemistry and Biochemistry Publications
In this paper, a novel self-healable and stretchable microfluidics system for next generation wearable lab-on-a-chip is presented. An imine-based precursor with various metal sources (Co(II), Fe(II), and Zn(II)) is used for the development of an intrinsically autonomous self-healing microfluidic device. Microfluidics fabrication is performed on the self-healing substrate layer using a mold transfer method. The mechanical properties of the resulting layer are evaluated using tensile strain pull testing. Microfluidic characteristics including fluid flow, wettability, leak, and fluorescence compatibility are investigated to understand its performance in classical microfluidic applications. The new microfluidic devices are also characterized using scanning-electron microscopy to evaluate …