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Full-Text Articles in Physical Sciences and Mathematics
Acth Promotes Osteogenesis Of Rat Mesenchymal Stem Cells Through The Melanocortin-2 Receptor, Jodi F. Evans Ph.D., Sylvana Rodriguez, Louis Ragolia
Acth Promotes Osteogenesis Of Rat Mesenchymal Stem Cells Through The Melanocortin-2 Receptor, Jodi F. Evans Ph.D., Sylvana Rodriguez, Louis Ragolia
Faculty Works: BCES (1999-2023)
Adrenocorticotropin Hormone (ACTH) is an endocrine hormone that is secreted by the pituitary and stimulates the secretion of cortisol from the adrenal cortex. It is among the several melanocortin peptide hormones that are derived from proopiomelanocortin (POMC) such as α-melanocyte stimulating hormone (α-MSH), γ-MSH and the endorphins. ACTH is also produced by cells outside the central nervous system and has been found to play a role in osteogenesis. Using mesenchymal stem cells (MSC) obtained from bone marrow of the Wystar Kyoto (WKY) rat, we confirmed that ACTH increases osteogenesis in a dosedependent manner. Immunoblot of crude membrane fractions was used …
High Glucose Enhances The Proliferation Effects Of Stress Hormones In Mesenchymal Stem Cell Cultures, Jodi F. Evans Ph.D., Nancy Abrego, Louis Ragolia
High Glucose Enhances The Proliferation Effects Of Stress Hormones In Mesenchymal Stem Cell Cultures, Jodi F. Evans Ph.D., Nancy Abrego, Louis Ragolia
Faculty Works: BCES (1999-2023)
Mesenchymal stem cells (MSC) are the progenitor cells to connective tissue cells, epithelial cells, and smooth muscle cells. These cells are currently being investigated as a cellular source for tissue regeneration and repair. The systemic and local tissue environment may have significant influence on the success of such efforts. We hypothesized that elevated glucose and exposure to stress hormones would influence the proliferation of MSC. MSC from the bone marrow of Wistar-Kyoto (WKY) rats were grown under both low glucose (5 mM) and high glucose (20 nM) conditions in the presence and absence of the synthetic glucocorticoid, dexamethasone, and adrenocorticotropin …