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Full-Text Articles in Physical Sciences and Mathematics
Identification Of Alternative Protein Targets Of Glutamate-Ureido-Lysine Associated With Psma Tracer Uptake In Prostate Cancer Cells, Martin K. Bakht, John J. Hayward, Farsheed Shahbazi-Raz, Magdalena Skubal, Ryo Tamura, Keith F. Stringer, Daniel Meister, Varadha Balaji Venkadakrishnan, Hui Xue, Adam Pillon, Mathew Stover, Adam Tronchin, Bre Anne Fifield, Lavleen Mader, Sheng Yu Ku, Gi Jeong Cheon, Keon Wook Kang, Yuzhuo Wang, Xuesen Dong, Himisha Beltran, Jan Grimm, Lis A. Porter, John F. Trant
Identification Of Alternative Protein Targets Of Glutamate-Ureido-Lysine Associated With Psma Tracer Uptake In Prostate Cancer Cells, Martin K. Bakht, John J. Hayward, Farsheed Shahbazi-Raz, Magdalena Skubal, Ryo Tamura, Keith F. Stringer, Daniel Meister, Varadha Balaji Venkadakrishnan, Hui Xue, Adam Pillon, Mathew Stover, Adam Tronchin, Bre Anne Fifield, Lavleen Mader, Sheng Yu Ku, Gi Jeong Cheon, Keon Wook Kang, Yuzhuo Wang, Xuesen Dong, Himisha Beltran, Jan Grimm, Lis A. Porter, John F. Trant
Chemistry and Biochemistry Publications
Prostate-specific membrane antigen (PSMA) is highly overexpressed in most prostate cancers and is clinically visualized using PSMA-specific probes incorporating glutamate-ureido-lysine (GUL). PSMA is effectively absent from certain high-mortality, treatment-resistant subsets of prostate cancers, such as neuroendocrine prostate cancer (NEPC); however, GUL-based PSMA tracers are still reported to have the potential to identify NEPC metastatic tumors. These probes may bind unknown proteins associated with PSMA-suppressed cancers. We have identified the up-regulation of PSMA-like aminopeptidase NAALADaseL and the metabotropic glutamate receptors (mGluRs) in PSMA-suppressed prostate cancers and find that their expression levels inversely correlate with PSMA expression and are associated with GUL-based …
Differential Expression Of Glucose Transporters And Hexokinases In Prostate Cancer With A Neuroendocrine Gene Signature: A Mechanistic Perspective For 18 F-Fdg Imaging Of Psma-Suppressed Tumors, Martin K. Bakht, Jessica M. Lovnicki, Janice Tubman, Keith F. Stringer, Jonathan Chiaramonte, Michael R. Reynolds, Iulian Derecichei, Rosa Maria Ferraiuolo, Bre Anne Fifield, Dorota Lubanska, So Won Oh, Gi Jeong Cheon, Cheol Kwak, Chang Wook Jeong, Keon Wook Kang, John F. Trant, Colm Morrissey, Ilsa M. Coleman, Yuzhuo Wang, Hojjat Ahmadzadehfar
Differential Expression Of Glucose Transporters And Hexokinases In Prostate Cancer With A Neuroendocrine Gene Signature: A Mechanistic Perspective For 18 F-Fdg Imaging Of Psma-Suppressed Tumors, Martin K. Bakht, Jessica M. Lovnicki, Janice Tubman, Keith F. Stringer, Jonathan Chiaramonte, Michael R. Reynolds, Iulian Derecichei, Rosa Maria Ferraiuolo, Bre Anne Fifield, Dorota Lubanska, So Won Oh, Gi Jeong Cheon, Cheol Kwak, Chang Wook Jeong, Keon Wook Kang, John F. Trant, Colm Morrissey, Ilsa M. Coleman, Yuzhuo Wang, Hojjat Ahmadzadehfar
Chemistry and Biochemistry Publications
Although the incidence of de novo neuroendocrine prostate cancer (PC) is rare, recent data suggest that low expression of prostatespecific membrane antigen (PSMA) is associated with a spectrum of neuroendocrine hallmarks and androgen receptor (AR) suppression in PC. Previous clinical reports indicate that PCs with a phenotype similar to neuroendocrine tumors can be more amenable to imaging by 18F-FDG than by PSMA-targeting radioligands. In this study, we evaluated the association between neuroendocrine gene signature and 18F-FDG uptake-associated genes including glucose transporters (GLUTs) and hexokinases, with the goal of providing a genomic signature to explain the reported 18F-FDG avidity of PSMA …