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Full-Text Articles in Physical Sciences and Mathematics
A Calorimetric, Volumetric And Combined Sans And Saxs Study Of Hybrid Siloxane Phosphocholine Bilayers, Mark B. Frampton, Doruntina Yakoub, John Katsaras, Paul M. Zelisko, Drew Marquardt
A Calorimetric, Volumetric And Combined Sans And Saxs Study Of Hybrid Siloxane Phosphocholine Bilayers, Mark B. Frampton, Doruntina Yakoub, John Katsaras, Paul M. Zelisko, Drew Marquardt
Chemistry and Biochemistry Publications
Siloxanes are molecules used extensively in commercial, industrial, and biomedical applications. The inclusion of short siloxane chains into phospholipids results in interesting physical properties, including the ability to form low polydispersity unilamellar vesicles. As such, hybrid siloxane phosphocholines (SiPCs) have been examined as a potential platform for the delivery of therapeutic agents. Using small angle X-ray and neutron scattering, vibrating tube densitometry, and differential scanning calorimetry, we studied four hybrid SiPCs bilayers. Lipid volume measurements for the different SiPCs compared well with those previously determined for polyunsaturated PCs. Furthermore, the different SiPC's membrane thicknesses increased monotonically with temperature and, for …
The Structures Of Polyunsaturated Lipid Bilayers By Joint Refinement Of Neutron And X-Ray Scattering Data, Drew Marquardt, Frederick A. Heberle, Jianjun Pan, Xiaolin Cheng, Georg Pabst, Thad A. Harroun, Norbert Kučerka, John Katsaras
The Structures Of Polyunsaturated Lipid Bilayers By Joint Refinement Of Neutron And X-Ray Scattering Data, Drew Marquardt, Frederick A. Heberle, Jianjun Pan, Xiaolin Cheng, Georg Pabst, Thad A. Harroun, Norbert Kučerka, John Katsaras
Chemistry and Biochemistry Publications
© 2020 Elsevier B.V. We present the detailed structural analysis of polyunsaturated fatty acid-containing phospholipids namely, 1-palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine (PDPC) and 1-stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine (SDPC). A newly developed molecular dynamics (MD) simulation parsing scheme for lipids containing fatty acids with multiple double bonds was implemented into the scattering density profile (SDP) model to simultaneously refine differently contrasted neutron and X-ray scattering data. SDP analyses of scattering data at 30 °C yielded lipid areas of 71.1 Å2 and 70.4 Å2 for PDPC and SDPC bilayers, respectively, and a model free analysis of PDPC at 30 °C resulted in a lipid area of 72 Å2. In …
Neutron Scattering At The Intersection Of Heart Health Science And Biophysics, Drew Marquardt, Richard J. Alsop, Maikel C. Rheinstädter, Thad A. Harroun
Neutron Scattering At The Intersection Of Heart Health Science And Biophysics, Drew Marquardt, Richard J. Alsop, Maikel C. Rheinstädter, Thad A. Harroun
Chemistry and Biochemistry Publications
There is an urgent quest for improved heart health. Here, we review how neutron radiation can provide insight into the molecular basis of heart health. Lower cholesterol, a daily intake of aspirin and supplemental vitamin E are argued to all improve heart health. However, the mechanisms behind these common regimens, and others, are not entirely understood. It is not clear why a daily intake of aspirin can help some people with heart disease, and the benefits of vitamin E in the treatment of reperfusion injury have been heavily debated. The molecular impact of cholesterol in the body is still a …