Physical Sciences and Mathematics Commons^™

Differential Expression Of Glucose Transporters And Hexokinases In Prostate Cancer With A Neuroendocrine Gene Signature: A Mechanistic Perspective For 18 F-Fdg Imaging Of Psma-Suppressed Tumors, Martin K. Bakht, Jessica M. Lovnicki, Janice Tubman, Keith F. Stringer, Jonathan Chiaramonte, Michael R. Reynolds, Iulian Derecichei, Rosa Maria Ferraiuolo, Bre Anne Fifield, Dorota Lubanska, So Won Oh, Gi Jeong Cheon, Cheol Kwak, Chang Wook Jeong, Keon Wook Kang, John F. Trant, Colm Morrissey, Ilsa M. Coleman, Yuzhuo Wang, Hojjat Ahmadzadehfar

Chemistry and Biochemistry Publications

Although the incidence of de novo neuroendocrine prostate cancer (PC) is rare, recent data suggest that low expression of prostatespecific membrane antigen (PSMA) is associated with a spectrum of neuroendocrine hallmarks and androgen receptor (AR) suppression in PC. Previous clinical reports indicate that PCs with a phenotype similar to neuroendocrine tumors can be more amenable to imaging by 18F-FDG than by PSMA-targeting radioligands. In this study, we evaluated the association between neuroendocrine gene signature and 18F-FDG uptake-associated genes including glucose transporters (GLUTs) and hexokinases, with the goal of providing a genomic signature to explain the reported 18F-FDG avidity of PSMA …